Table 3 Overall survival for sex, age, pathology features and GST Pi by chemotherapy interaction
| Â | Bivariate HR* | Bivariate p value | Multivariable HR (95% CI) | Multivariable p value |
|---|---|---|---|---|
GST Pi by chemotherapy interaction | -- | -- | 1.4 (1.2–1.8) | <0.001 |
Male sex | 1.0 | 0.850 | -- | -- |
Age ≥ 75 years | 1.7 | 0.044 | 1.5 (0.9–2.6) | 0.153 |
Right colon tumor | 0.7 | 0.063 | 0.8 (0.5–1.3) | 0.431 |
Size ≥ 5 cm | 1.3 | 0.193 | -- | -- |
Spread beyond muscularis propria | 3.0 | 0.030 | 1.6 (0.6–4.6) | 0.356 |
Mucinous or signet ring | 1.1 | 0.730 | -- | -- |
≥ 4 lymph nodes involved | 2.5 | <0.001 | 1.5 (0.97–2.4) | 0.071 |
Apical node involved | 2.8 | <0.001 | 2.0 (1.1–3.5) | 0.021 |
High grade tumor | 2.3 | <0.001 | 1.7 (1.1–2.7) | 0.016 |
Venous invasion present | 1.5 | 0.084 | 1.2 (0.8–1.9) | 0.418 |
Free serosal surface involved | 3.3 | <0.001 | 2.0 (1.2–3.1) | 0.004 |
Adjacent structure infiltrated | 1.3 | 0.455 | -- | -- |