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Table 2 Association of SNPs in microRNA biogenesis pathway genes and breast cancer survival

From: Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival

Gene SNP Position Major/Minor allele MAFa Disease-free survival   Overall survival  
Genetic model aHR (95 % CI) b P FDR P Genetic
model
aHR (95 % CI) c P FDR P
AGO1 rs595055 intron G/A 0.17 REC 1.86 (0.65-5.30) 0.247 0.47 ADD 0.66 (0.36-1.21) 0.181 0.44
  rs11263833 intron T/G 0.24 REC 1.35 (0.56-3.27) 0.500 0.61 REC 0.56 (0.13-2.38) 0.430 0.60
AGO2 rs2292779 intron C/G 0.38 ADD 1.42 (1.06-1.92) 0.021 0.27 REC 2.94 (1.52-5.69) 0.001 0.05
  rs3864659 intron A/C 0.05 ADD 0.85 (0.44-1.62) 0.619 0.69 DOM 1.11 (0.43-2.85) 0.825 0.93
  rs7016981 intron T/C 0.10 ADD 0.77 (0.46-1.30) 0.326 0.49 DOM 1.48 (0.75-2.91) 0.254 0.50
  rs7824304 intron C/T 0.05 ADD 0.53 (0.24-1.18) 0.120 0.36 ADD 0.59 (0.20-1.75) 0.340 0.57
  rs11786030 3’ UTR A/G 0.48 DOM 2.62 (1.41-4.88) 0.002 0.09 DOM 2.41 (1.05-5.50) 0.037 0.38
DGCR8 rs2073779 intron T/C 0.08 DOM 0.89 (0.50-1.60) 0.706 0.72 ADD 0.92 (0.43-1.97) 0.836 0.93
  rs9605062 intron T/C 0.14 ADD 0.65 (0.40-1.06) 0.084 0.34 ADD 0.62 (0.30-1.26) 0.186 0.44
  rs9606250 intron A/T 0.05 DOM 0.21 (0.05-0.84) 0.028 0.28 - - - 0.99
DICER1 rs1057035 3’ UTR T/C 0.09 DOM 1.72 (0.99-2.99) 0.054 0.31 DOM 2.08 (1.01-4.28) 0.047 0.38
  rs2282265 intron A/G 0.45 REC 1.70 (0.99-2.91) 0.055 0.31 DOM 0.87 (0.44-1.74) 0.700 0.85
DROSHA rs644236 intron C/T 0.31 REC 0.80 (0.41-1.58) 0.517 0.61 ADD 0.73 (0.46-1.15) 0.173 0.44
  rs874332 intron T/C 0.47 REC 1.25 (0.76-2.05) 0.382 0.54 REC 2.24 (1.21-4.17) 0.011 0.21
  rs7737174 intron G/A 0.46 REC 1.13 (0.69-1.85) 0.639 0.69 REC 0.76 (0.36-1.61) 0.469 0.60
  rs10461898 intron A/G 0.23 REC 1.75 (0.68-4.46) 0.244 0.47 ADD 1.44 (0.86-2.41) 0.170 0.44
  rs11748548 intron G/A 0.26 DOM 0.79 (0.51-1.24) 0.307 0.49 ADD 0.71 (0.43-1.16) 0.167 0.44
  rs16901096 intron C/T 0.21 DOM 0.73 (0.46-1.16) 0.185 0.44 DOM 0.58 (0.30-1.11) 0.098 0.44
FMR1 rs25704 3’ UTR T/C 0.35 DOM 1.27 (0.82-1.97) 0.287 0.49 DOM 1.39 (0.74-2.61) 0.302 0.52
  rs28900 intron A/C 0.46 DOM 1.21 (0.75-1.94) 0.443 0.59 DOM 1.63 (0.81-3.29) 0.175 0.44
  rs971000 intron C/T 0.33 DOM 1.45 (0.94-2.23) 0.095 0.35 DOM 1.71 (0.92-3.18) 0.089 0.44
GEMIN3 rs197413 V642V G/A 0.39 REC 1.33 (0.78-2.26) 0.299 0.49 REC 0.65 (0.25-1.66) 0.368 0.58
  rs17569368 intron A/T 0.09 DOM 1.38 (0.80-2.37) 0.242 0.47 DOM 1.14 (0.54-2.42) 0.727 0.86
GEMIN4 rs7813 C1033R T/C 0.35 ADD 0.77 (0.56-1.07) 0.126 0.36 REC 0.69 (0.27-1.82) 0.459 0.60
  rs2740349 N929D A/G 0.13 DOM 0.83 (0.47-1.44) 0.502 0.61 DOM 0.81 (0.37-1.79) 0.604 0.76
  rs3744741 Q684R C/T 0.22 REC 1.21 (0.52-2.81) 0.662 0.7 REC 1.83 (0.64-5.28) 0.262 0.50
  rs4968104 E593V T/A 0.15 DOM 0.62 (0.36-1.06) 0.078 0.34 ADD 0.46 (0.21-0.99) 0.048 0.38
HIWI rs4759659 intron G/A 0.14 ADD 0.50 (0.29-0.85) 0.011 0.22 ADD 0.67 (0.32-1.39) 0.281 0.51
  rs7963072 intron G/A 0.1 REC 1.71 (0.23-12.7) 0.598 0.68 REC 4.30 (0.57-32.5) 0.158 0.44
  rs1106042 K527R G/A 0.11 DOM 1.05 (0.61-1.82) 0.859 0.86 DOM 1.04 (0.50-2.16) 0.908 0.95
  rs11060845 intron G/T 0.4 ADD 1.36 (1.00-1.85) 0.054 0.31 DOM 1.76 (0.88-3.54) 0.110 0.44
p68 rs1991401 5’ UTR A/G 0.36 ADD 0.87 (0.63-1.20) 0.391 0.54 REC 1.35 (0.60-3.07) 0.467 0.60
p72 rs138457 intron T/C 0.5 ADD 1.19 (0.87-1.63) 0.274 0.49 DOM 1.80 (0.83-3.90) 0.134 0.44
  rs138462 3’ UTR A/G 0.12 REC 1.60 (0.38-6.69) 0.519 0.61 DOM 0.72 (0.35-1.48) 0.378 0.58
  rs12627803 intron T/C 0.21 REC 0.53 (0.15-1.91) 0.329 0.49 DOM 1.27 (0.69-2.33) 0.446 0.60
  rs2267390 intron C/T 0.37 REC 0.58 (0.27-1.23) 0.156 0.42 REC 0.45 (0.14-1.47) 0.186 0.44
  rs5750609 intron C/T 0.16 REC 0.28 (0.04-2.06) 0.213 0.47 ADD 0.69 (0.37-1.28) 0.245 0.50
RAN rs7958223 intron C/A 0.2 DOM 1.35 (0.88-2.07) 0.176 0.44 REC 2.02 (0.60-6.78) 0.257 0.50
  rs10848236 intron G/A 0.16 DOM 1.52 (0.98-2.37) 0.062 0.31 ADD 1.03 (0.58-1.84) 0.909 0.95
XPO5 rs11077 3’ UTR A/C 0.09 ADD 0.56 (0.27-1.18) 0.128 0.36 ADD 0.96 (0.44-2.09) 0.922 0.95
  1. NOTE ADD, additive model; DOM, dominant model; REC, recessive model.
  2. a Major/minor alleles and frequencies as determined by the distribution among all patients.
  3. b Adjusted for age, tumor size (≤2 cm and >2 cm), lymph-node involvement (no and yes), histologic grade (I-II and III), nuclear grade (I-II and III) and ER status (positive and negative), PR status (positive and negative) and hormone receptor therapy (yes and no).
  4. c Adjusted for age, tumor size (≤2 cm and >2 cm), lymph-node involvement (no and yes), metastasis (no and yes), histologic grade (I-II and III), and hormone receptor therapy (yes and no).