Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival

Sung, Hyuna; Jeon, Sujee; Lee, Kyoung-Mu; Han, Sohee; Song, Minkyo; Choi, Ji-Yeob; Park, Sue K; Yoo, Keun-Young; Noh, Dong-Young; Ahn, Sei-Hyun; Kang, Daehee

doi:10.1186/1471-2407-12-195

BMC Cancer

Table 2 Association of SNPs in microRNA biogenesis pathway genes and breast cancer survival

From: Common genetic polymorphisms of microRNA biogenesis pathway genes and breast cancer survival

Gene	SNP	Position	Major/Minor allele	MAF^a	Disease-free survival				Overall survival
Gene	SNP	Position	Major/Minor allele	MAF^a	Genetic model	aHR (95 % CI) ^b	P	FDR P	Genetic model	aHR (95 % CI) ^c	P	FDR P
AGO1	rs595055	intron	G/A	0.17	REC	1.86 (0.65-5.30)	0.247	0.47	ADD	0.66 (0.36-1.21)	0.181	0.44
	rs11263833	intron	T/G	0.24	REC	1.35 (0.56-3.27)	0.500	0.61	REC	0.56 (0.13-2.38)	0.430	0.60
AGO2	rs2292779	intron	C/G	0.38	ADD	1.42 (1.06-1.92)	0.021	0.27	REC	2.94 (1.52-5.69)	0.001	0.05
	rs3864659	intron	A/C	0.05	ADD	0.85 (0.44-1.62)	0.619	0.69	DOM	1.11 (0.43-2.85)	0.825	0.93
	rs7016981	intron	T/C	0.10	ADD	0.77 (0.46-1.30)	0.326	0.49	DOM	1.48 (0.75-2.91)	0.254	0.50
	rs7824304	intron	C/T	0.05	ADD	0.53 (0.24-1.18)	0.120	0.36	ADD	0.59 (0.20-1.75)	0.340	0.57
	rs11786030	3’ UTR	A/G	0.48	DOM	2.62 (1.41-4.88)	0.002	0.09	DOM	2.41 (1.05-5.50)	0.037	0.38
DGCR8	rs2073779	intron	T/C	0.08	DOM	0.89 (0.50-1.60)	0.706	0.72	ADD	0.92 (0.43-1.97)	0.836	0.93
	rs9605062	intron	T/C	0.14	ADD	0.65 (0.40-1.06)	0.084	0.34	ADD	0.62 (0.30-1.26)	0.186	0.44
	rs9606250	intron	A/T	0.05	DOM	0.21 (0.05-0.84)	0.028	0.28	-	-	-	0.99
DICER1	rs1057035	3’ UTR	T/C	0.09	DOM	1.72 (0.99-2.99)	0.054	0.31	DOM	2.08 (1.01-4.28)	0.047	0.38
	rs2282265	intron	A/G	0.45	REC	1.70 (0.99-2.91)	0.055	0.31	DOM	0.87 (0.44-1.74)	0.700	0.85
DROSHA	rs644236	intron	C/T	0.31	REC	0.80 (0.41-1.58)	0.517	0.61	ADD	0.73 (0.46-1.15)	0.173	0.44
	rs874332	intron	T/C	0.47	REC	1.25 (0.76-2.05)	0.382	0.54	REC	2.24 (1.21-4.17)	0.011	0.21
	rs7737174	intron	G/A	0.46	REC	1.13 (0.69-1.85)	0.639	0.69	REC	0.76 (0.36-1.61)	0.469	0.60
	rs10461898	intron	A/G	0.23	REC	1.75 (0.68-4.46)	0.244	0.47	ADD	1.44 (0.86-2.41)	0.170	0.44
	rs11748548	intron	G/A	0.26	DOM	0.79 (0.51-1.24)	0.307	0.49	ADD	0.71 (0.43-1.16)	0.167	0.44
	rs16901096	intron	C/T	0.21	DOM	0.73 (0.46-1.16)	0.185	0.44	DOM	0.58 (0.30-1.11)	0.098	0.44
FMR1	rs25704	3’ UTR	T/C	0.35	DOM	1.27 (0.82-1.97)	0.287	0.49	DOM	1.39 (0.74-2.61)	0.302	0.52
	rs28900	intron	A/C	0.46	DOM	1.21 (0.75-1.94)	0.443	0.59	DOM	1.63 (0.81-3.29)	0.175	0.44
	rs971000	intron	C/T	0.33	DOM	1.45 (0.94-2.23)	0.095	0.35	DOM	1.71 (0.92-3.18)	0.089	0.44
GEMIN3	rs197413	V642V	G/A	0.39	REC	1.33 (0.78-2.26)	0.299	0.49	REC	0.65 (0.25-1.66)	0.368	0.58
	rs17569368	intron	A/T	0.09	DOM	1.38 (0.80-2.37)	0.242	0.47	DOM	1.14 (0.54-2.42)	0.727	0.86
GEMIN4	rs7813	C1033R	T/C	0.35	ADD	0.77 (0.56-1.07)	0.126	0.36	REC	0.69 (0.27-1.82)	0.459	0.60
	rs2740349	N929D	A/G	0.13	DOM	0.83 (0.47-1.44)	0.502	0.61	DOM	0.81 (0.37-1.79)	0.604	0.76
	rs3744741	Q684R	C/T	0.22	REC	1.21 (0.52-2.81)	0.662	0.7	REC	1.83 (0.64-5.28)	0.262	0.50
	rs4968104	E593V	T/A	0.15	DOM	0.62 (0.36-1.06)	0.078	0.34	ADD	0.46 (0.21-0.99)	0.048	0.38
HIWI	rs4759659	intron	G/A	0.14	ADD	0.50 (0.29-0.85)	0.011	0.22	ADD	0.67 (0.32-1.39)	0.281	0.51
	rs7963072	intron	G/A	0.1	REC	1.71 (0.23-12.7)	0.598	0.68	REC	4.30 (0.57-32.5)	0.158	0.44
	rs1106042	K527R	G/A	0.11	DOM	1.05 (0.61-1.82)	0.859	0.86	DOM	1.04 (0.50-2.16)	0.908	0.95
	rs11060845	intron	G/T	0.4	ADD	1.36 (1.00-1.85)	0.054	0.31	DOM	1.76 (0.88-3.54)	0.110	0.44
p68	rs1991401	5’ UTR	A/G	0.36	ADD	0.87 (0.63-1.20)	0.391	0.54	REC	1.35 (0.60-3.07)	0.467	0.60
p72	rs138457	intron	T/C	0.5	ADD	1.19 (0.87-1.63)	0.274	0.49	DOM	1.80 (0.83-3.90)	0.134	0.44
	rs138462	3’ UTR	A/G	0.12	REC	1.60 (0.38-6.69)	0.519	0.61	DOM	0.72 (0.35-1.48)	0.378	0.58
	rs12627803	intron	T/C	0.21	REC	0.53 (0.15-1.91)	0.329	0.49	DOM	1.27 (0.69-2.33)	0.446	0.60
	rs2267390	intron	C/T	0.37	REC	0.58 (0.27-1.23)	0.156	0.42	REC	0.45 (0.14-1.47)	0.186	0.44
	rs5750609	intron	C/T	0.16	REC	0.28 (0.04-2.06)	0.213	0.47	ADD	0.69 (0.37-1.28)	0.245	0.50
RAN	rs7958223	intron	C/A	0.2	DOM	1.35 (0.88-2.07)	0.176	0.44	REC	2.02 (0.60-6.78)	0.257	0.50
	rs10848236	intron	G/A	0.16	DOM	1.52 (0.98-2.37)	0.062	0.31	ADD	1.03 (0.58-1.84)	0.909	0.95
XPO5	rs11077	3’ UTR	A/C	0.09	ADD	0.56 (0.27-1.18)	0.128	0.36	ADD	0.96 (0.44-2.09)	0.922	0.95

NOTE ADD, additive model; DOM, dominant model; REC, recessive model.
^a Major/minor alleles and frequencies as determined by the distribution among all patients.
^b Adjusted for age, tumor size (≤2 cm and >2 cm), lymph-node involvement (no and yes), histologic grade (I-II and III), nuclear grade (I-II and III) and ER status (positive and negative), PR status (positive and negative) and hormone receptor therapy (yes and no).
^c Adjusted for age, tumor size (≤2 cm and >2 cm), lymph-node involvement (no and yes), metastasis (no and yes), histologic grade (I-II and III), and hormone receptor therapy (yes and no).

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ISSN: 1471-2407

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