| |
Combined score a
|
No. of total patients ( N =303)
|
No. of events ( N =87)
|
Adjusted HRb(95% CI)
|
P
|
P
interaction
|
|---|
|
BMI < 25
|
t1
|
81
|
17
|
1.00 (reference)
| |
0.031
|
|
N=229
|
t2
|
77
|
20
|
1.74 (0.88-3.42)
|
0.110
| |
| |
t3
|
71
|
25
|
3.17 (1.66-6.06)
|
<.0001
| |
| |
P
trend
| | |
1.78 (1.29-2.46)
|
<.0001
| |
|
BMI ≥ 25
|
t1
|
20
|
13
|
1.00 (reference)
| | |
|
N =74
|
t2
|
23
|
15
|
0.92 (0.27-3.08)
|
0.886
| |
| |
t3
|
31
|
21
|
0.92 (0.32-2.63)
|
0.881
| |
| |
P
trend
| | |
0.96 (0.57-1.62)
|
0.891
| |
|
LN –
|
t1
|
57
|
9
|
1.00 (reference)
| |
0.094
|
|
N =170
|
t2
|
55
|
12
|
3.28 (1.19-9.07)
|
0.022
| |
| |
t3
|
58
|
19
|
5.36 (2.18-13.2)
|
<.0001
| |
| |
P
trend
| | |
2.21 (1.45-3.35)
|
<.0001
| |
|
LN +
|
low
|
44
|
29
|
1.00 (reference)
| | |
|
N =133
|
medium
|
45
|
29
|
1.31 (0.64-2.68)
|
0.462
| |
| |
high
|
44
|
28
|
1.43 (0.69-2.95)
|
0.335
| |
| |
P
trend
| | |
1.20 (0.84-1.71)
|
0.328
| |
-
a The subjects were categorized into three groups based on the tertiles of combined score: low (1.092-3.463), medium (3.464-4.997) and high (4.998-14.276) score groups.
-
b Adjusted for BMI (< 25 and ≥ 25 kg/m2), TNM stage (I, II, and III), ER status (positive and negative) and radiation therapy (Yes and No). For stratified analysis by BMI group, the stratification variable of interest (BMI) was not included as covariate in the model.
- LN –, lymph-node negative; LN +, lymph-node positive.
