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Table 2 The distributions of demographic and clinicophathological characteristics according to tertile of lipocalin-2 and MMP-9 in all patients

From: The association between the preoperative serum levels of lipocalin-2 and matrix metalloproteinase-9 (MMP-9) and prognosis of breast cancer

  Lipocalin-2 (ng/ml) MMP-9 (ng/ml)
  t1 t2 t3      P trend a
  (2.63-59.03) (59.03-109.65) (109.65-772.34)   (0.15-34.42) (34.42-80.36) (80.36-397.09)
Age, mean (SD) 46.5 (11.6) 47.3 (10.6) 45.9 (9.9) 0.67b 48.2 (10.5) 44.4 (9.8) 47.1 (11.5) 0.58b
Premenopausal status, % 65.0 60.4 64.4 0.93 53.0 72.6 64.0 0.11
BMI < 25 kg/m2, % 82.0 74.5 70.3 0.05 77.0 78.4 71.3 0.35
TNM stage, %
  I 32.0 40.2 41.6 0.59 35.0 46.1 32.7 0.72
  IIA –IIB 48.0 39.2 34.7   39.0 35.3 47.5  
  IIIA –IIIC 20.0 20.6 23.8   26.0 18.6 19.8  
Tumor size < 2cm, % 46.0 53.9 57.4 0.11 47.0 62.8 47.5 0.95
Lymph-node negative, % 57.0 54.9 56.4 0.94 55.0 60.8 52.5 0.72
Histologic grade I-II, % 48.9 61.2 55.7 0.36 48.4 62.2 55.2 0.35
Nuclear grade I-II, % 51.6 58.0 54.1 0.73 52.1 57.0 54.6 0.72
ER positive, % 56.0 59.8 55.5 0.94 53.0 61.8 56.4 0.63
PR positive, % 51.0 54.9 51.5 0.95 48.0 58.8 50.5 0.73
Adjuvant chemotherapy Yes, % 75.8 66.7 75.8 0.99 74.2 70.0 74.0 0.98
Radiation therapy Yes, % 62.2 58.0 65.0 0.69 67.7 60.6 57.0 0.12
Hormone receptor therapy Yes, % 63.6 69.0 66.0 0.73 62.6 70.0 66.0 0.61
  1. a Mantel-Haenszel chi-square test.
  2. b Pearson correlation coefficients test.