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Table 1 VEGF-R mRNA expression in leukemia and lymphoma cell lines

From: DNA methylation regulates expression of VEGF-R2 (KDR) and VEGF-R3 (FLT4)

    KDR    
  +++ ++ + (+) -
AML 0 2 0 3 16 21
pre-B ALL 0 0 0 1 10 11
T-ALL 0 0 0 2 9 11
NK 0 0 0 0 5 5
CML 1 0 0 1 12 14
HL 0 0 0 0 5 5
ALCL 0 0 0 0 5 5
BL 0 0 0 0 5 5
DLBCL 0 0 0 0 5 5
FL 0 0 0 0 5 5
MCL 0 0 0 0 5 5
1 2 0 7 82 92
    FLT4    
  +++ ++ + (+) -
AML 0 2 4 3 14 23
pre-B ALL 0 3 1 3 4 11
T-ALL 0 0 2 4 5 11
NK 0 0 0 0 5 5
CML 0 1 1 3 10 15
HL 0 0 0 1 4 5
ALCL 0 0 0 0 5 5
BL 0 0 0 0 5 5
DLBCL 0 0 0 0 5 5
FL 0 0 0 0 5 5
MCL 0 0 0 0 5 5
0 6 8 14 67 95
  1. KDR and FLT4 mRNA expression levels were determined by quantitative real-time PCR. TBP expression was used as endogenous control and cell lines CMK (KDR) and HEL (FLT4) were used for normalization. Relative quantification: +++ ≥ 5; ++ ≥ 1; + ≥ 0.2; (+) ≥ 0.04;- < 0.04. AML, acute myeloid leukemia; ALL, acute lymphoblastic leukemia; NK, natural killer leukemia; CML, chronic myeloid leukemia; HL, Hodgkin lymphoma; ALCL, anaplastic large cell lymphoma; BL, Burkitt lymphoma; DLBCL, diffuse large B cell lymphoma; FL, follicular lymphoma, MCL, mantle cell lymphoma