Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study

Table 5 Risk of CRC in relation to fibre intake subdivided by IL10 genotype combinations

	Crude IRR (95% CI)^a	Adjusted IRR (95% CI)^b	P_Interaction ^c
	Intake of dietary fibre (per 10 g/day)
rs3024505/C-592A (rs1800872)
wt/wt	0.64 (0.43-0.93)	0.65 (0.44-0.96)
wt/variant	0.53 (0.34-0.83)	0.55 (0.35-0.86)
variant/variant	0.72 (0.36-1.44)	0.75 (0.38-1.47)
variant/wt	1.18 (0.86-1.62)	1.19 (0.87-1.65)	0.19

^a Crude analysis.
^b Analysis adjusted for smoking status, alcohol, HRT status (women only), BMI, use of NSAID, and intake of red and processed meat and dietary fibre.
^c P-value for interaction between polymorphisms and dietary factors for the adjusted estimates.

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