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Table 3 Interaction between dietary factors and the studied IL10 polymorphisms in relation to colorectal cancer risk

From: Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study

 

Crude IRR (95% CI)a

Adjusted IRR (95% CI)b

PInteraction c

 

Intake of red and processed meat (per 25 g/day)

rs3024505

CC

1.02 (0.96-1.07)

1.02 (0.96-1.08)

 

CT and TT

1.02 (0.96-1.09)

1.03 (0.96-1.10)

0.78

C-592A (rs1800872)

CC

1.01 (0.96-1.06)

1.02 (0.97-1.07)

 

AC and AA

1.03 (0.96-1.11)

1.02 (0.95-1.11)

0.92

 

Intake of dietary fibre (per 10 g/day)

rs3024505

CC

0.70 (0.59-0.84)

0.73 (0.60-0.88)

 

CT and TT

1.10 (0.83-1.46)

1.12 (0.84-1.49)

0.01

C-592A (rs1800872)

CC

0.88 (0.73-1.06)

0.90 (0.74-1.09)

 

AC and AA

0.67 (0.51-0.88)

0.71 (0.54-0.93)

0.15

Intake of cereals (per 50 g/day)

rs3024505

CC

0.89 (0.82-0.97)

0.99 (0.88-1.12)

 

CT and TT

1.03 (0.91-1.16)

1.13 (0.98-1.30)

0.09

C-592A (rs1800872)

CC

0.95 (0.87-1.04)

1.05 (0.93-1.18)

 

AC and AA

0.91 (0.81-1.02)

1.01 (0.88-1.16)

0.63

Intake of fish (per 25 g/day)

rs3024505

CC

0.88 (0.78-1.00)

0.89 (0.79-1.01)

 

CT and TT

0.95 (0.76-1.20)

0.97 (0.77-1.24)

0.51

C-592A (rs1800872)

CC

0.85 (0.74-0.97)

0.85 (0.74-0.98)

 

AC and AA

1.01 (0.84-1.21)

1.03 (0.86-1.24)

0.09

  1. a Crude analysis.
  2. b Analysis adjusted for smoking status, alcohol, HRT status (women only), BMI, use of NSAID, and intake of red and processed meat and dietary fibre.
  3. c P-value for interaction between polymorphisms and dietary factors for the adjusted estimates.