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Table 3 Interaction between dietary factors and the studied IL10 polymorphisms in relation to colorectal cancer risk

From: Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study

  Crude IRR (95% CI)a Adjusted IRR (95% CI)b PInteraction c
  Intake of red and processed meat (per 25 g/day)
rs3024505
CC 1.02 (0.96-1.07) 1.02 (0.96-1.08)  
CT and TT 1.02 (0.96-1.09) 1.03 (0.96-1.10) 0.78
C-592A (rs1800872)
CC 1.01 (0.96-1.06) 1.02 (0.97-1.07)  
AC and AA 1.03 (0.96-1.11) 1.02 (0.95-1.11) 0.92
  Intake of dietary fibre (per 10 g/day)
rs3024505
CC 0.70 (0.59-0.84) 0.73 (0.60-0.88)  
CT and TT 1.10 (0.83-1.46) 1.12 (0.84-1.49) 0.01
C-592A (rs1800872)
CC 0.88 (0.73-1.06) 0.90 (0.74-1.09)  
AC and AA 0.67 (0.51-0.88) 0.71 (0.54-0.93) 0.15
Intake of cereals (per 50 g/day)
rs3024505
CC 0.89 (0.82-0.97) 0.99 (0.88-1.12)  
CT and TT 1.03 (0.91-1.16) 1.13 (0.98-1.30) 0.09
C-592A (rs1800872)
CC 0.95 (0.87-1.04) 1.05 (0.93-1.18)  
AC and AA 0.91 (0.81-1.02) 1.01 (0.88-1.16) 0.63
Intake of fish (per 25 g/day)
rs3024505
CC 0.88 (0.78-1.00) 0.89 (0.79-1.01)  
CT and TT 0.95 (0.76-1.20) 0.97 (0.77-1.24) 0.51
C-592A (rs1800872)
CC 0.85 (0.74-0.97) 0.85 (0.74-0.98)  
AC and AA 1.01 (0.84-1.21) 1.03 (0.86-1.24) 0.09
  1. a Crude analysis.
  2. b Analysis adjusted for smoking status, alcohol, HRT status (women only), BMI, use of NSAID, and intake of red and processed meat and dietary fibre.
  3. c P-value for interaction between polymorphisms and dietary factors for the adjusted estimates.