Interaction between interleukin-10 (IL-10) polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case-cohort study

Table 2 Incidence rate ratios and 95% confidence intervals for the studied IL10 gene polymorphisms in the diet, cancer and health study

	N_Case	N_Subcohort	Crude IRR (95% CI)^a	Adjusted IRR (95% CI)^b	P-value^c
rs3024505
CC	268	553	1.00	1.00	-
CT	99	202	0.99 (0.79-1.25)	1.01 (0.80-1.28)	0.91
TT	11	20	1.15 (0.63-2.10)	1.11 (0.61-2.03)	0.73
CT and TT	110	222	1.01 (0.81-1.26)	1.02 (0.82-1.28)	0.85
C-592A (rs1800872)^d
CC	238	470	1.00	1.00	-
AC	116	261	0.91 (0.73-1.14)	0.90 (0.72-1.12)	0.36
AA	24	44	1.11 (0.74-1.67)	1.10 (0.73-1.65)	0.65
AC and AA	140	305	0.94 (0.77-1.16)	0.93 (0.76-1.14)	0.50

^a Crude analyses.
^b Analyses adjusted for smoking status, alcohol, HRT status (women only), BMI, use of NSAID, and intake of red and processed meat and dietary fibre.
^c P-value for the adjusted estimates.
^dData for IL10 rs1800872 were taken from (38).

ISSN: 1471-2407