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Table 1 Genes altered by chronic DcR3 exposure by real time RT-PCR array

From: DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1

  SKOV-3 OVCAR-3 CaOV3
UP BRCA1, CDC25A,Chk2,BAD, GZMA, DR3, Fas, ITGA4,B1and B3,MTSS1, SYK, ANGPT1, IL8, PDGFB, TEK, TGFB1, THBS1, MET, MMP1, MTA2,NME1, NME4.PLAU,PLAUR, SERPINE1 BRCA1, CCNE1, S100A4, GZMA, HTATIP2, Fas, FOS, MAP2K1/MEK, NFKB1A, SNGC, ANGPT2, INF-A, INF-B, PDGFA, TNF, MMP2, SERPINE1, TIMP3 CDKN1A (P21), S100A4, TERT, DR3, ITGB3, COL18A1, INF-B, PDGFA, TEK, TGFB1, VEGFA, MMP1, PLAU, SERPINE1, TIMP1
DOWN ATM, CDKN2A (P16), E2F1, APAF1, BCL2, FOS, ITGB5, ANGPT2, COL18A1, FGFR2, INF-A, INF-B, TGFBR1, TNF, VEGFA, MMP2, MMP9 CHK2, E2F1, TP53, DR3, PIK3R1, ETS2, ITGA4,B3, MCAM,MTSS1, ANGPT1, COL18A1, THBS1, MMP1, MMP9, MTA2, PLAU, SERPINB5, TWIST1 BRCA1, CCNE1, CDK2,CDK4,CHK2, MDM2, DR5, PIK3R1, SNGC, INTGB1, ANGPT1, ANGPT2, FGFR2, PDGFB, THBS1, MET, TIMP3, TWIST1