Table 1 Genes altered by chronic DcR3 exposure by real time RT-PCR array

UP

BRCA1, CDC25A,Chk2,BAD, GZMA, DR3, Fas, ITGA4,B1and B3,MTSS1, SYK, ANGPT1, IL8, PDGFB, TEK, TGFB1, THBS1, MET, MMP1, MTA2,NME1, NME4.PLAU,PLAUR, SERPINE1

BRCA1, CCNE1, S100A4, GZMA, HTATIP2, Fas, FOS, MAP2K1/MEK, NFKB1A, SNGC, ANGPT2, INF-A, INF-B, PDGFA, TNF, MMP2, SERPINE1, TIMP3

CDKN1A (P21), S100A4, TERT, DR3, ITGB3, COL18A1, INF-B, PDGFA, TEK, TGFB1, VEGFA, MMP1, PLAU, SERPINE1, TIMP1

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ATM, CDKN2A (P16), E2F1, APAF1, BCL2, FOS, ITGB5, ANGPT2, COL18A1, FGFR2, INF-A, INF-B, TGFBR1, TNF, VEGFA, MMP2, MMP9

CHK2, E2F1, TP53, DR3, PIK3R1, ETS2, ITGA4,B3, MCAM,MTSS1, ANGPT1, COL18A1, THBS1, MMP1, MMP9, MTA2, PLAU, SERPINB5, TWIST1

BRCA1, CCNE1, CDK2,CDK4,CHK2, MDM2, DR5, PIK3R1, SNGC, INTGB1, ANGPT1, ANGPT2, FGFR2, PDGFB, THBS1, MET, TIMP3, TWIST1