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Figure 9 | BMC Cancer

Figure 9

From: DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1

Figure 9

BRCA1 mRNA and protein expression are modulated by DcR3. Real time reverse transcriptase PCR (A. means of triplicate samples by RT-PCR and B. examples of individual melt curves) and Western Blot (C) for BRCA1 demonstrate that the differential changes in BRCA1 expression between SKOV-3/OVCAR-3 and CaOV-3 cells exposed to DcR3 are in line with the changes seen in platinum responsiveness from the same DcR3 treated cultures.

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BMC Cancer

ISSN: 1471-2407

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