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Figure 5 | BMC Cancer

Figure 5

From: DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1

Figure 5

Ovarian cancer cells express cell surface Heparan Sulfate Proteoglycans known to bind DcR3. Flow cytometry demonstrates the presence of the known DcR3 binding HSPGs, Syndecan-2 and CD44v3 on the surface of EOC cell lines. Syndecan-2 is the dominant HSPG in SKOV-3 and OVCAR-3 cells where in CaOV-3 Syndecan-2 expression is half that of the other two cell lines but CD44v3 expression is tenfold higher than the other lines.

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BMC Cancer

ISSN: 1471-2407

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