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Figure 3 | BMC Cancer

Figure 3

From: DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1

Figure 3

Ovarian cancer cell lines bind DcR3. A. Flow cytometry shows that there is no baseline cell surface DcR3 on the EOC cell lines tested (upper row) however recombinant human DcR3 (rhDcR3-Fc, R&D Systems) binds to the surface of EOC cell lines (lower row). Incubated with 1 μg rhDcR3-Fc, SKOV-3 binds the most DcR3 and CaOV-3 binds the least DcR3. B, DcR3 binding, defined as MFI by flow cytometry (solid black bars) is in direct proportion to the cell lines sensitivity to platinum (grey hatched bars) consistent with the clinical association of DcR3 to platinum resistant disease (CDDP = Cis-platinum 2.5 μg/ml).

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BMC Cancer

ISSN: 1471-2407

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