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Figure 1 | BMC Cancer

Figure 1

From: DcR3 binds to ovarian cancer via heparan sulfate proteoglycans and modulates tumor cells response to platinum with corresponding alteration in the expression of BRCA1

Figure 1

HIGH ascites levels of DcR3 are associated with platinum resistance in women with EOC. Ascites from forty five women with stage IIIC-IVA ovarian cancer were tested for DcR3 by ELISA and the cohort divided at the median level into HIGH and LOW DcR3 groups. A. Women with HIGH DcR3 were almost twice as likely to have platinum resistant disease. B. As would be expected women in this population with platinum resistant disease had significantly shorter overall survival (see ref. 8). C. Women with HIGH DcR3 levels had a significantly shorter time to first recurrence after primary therapy and a trend (D) towards shorter overall survival.

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BMC Cancer

ISSN: 1471-2407

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