IDR-E804 inhibits angiogenesis and cell proliferation and induces apoptosis in mouse tumors. (A) Immunohistochemistry was performed in tumor tissues derived from vehicle and IDR-E804 treated mice on day 20 to measure angiogenesis by CD31 staining, cell proliferation by Ki-67 staining and apoptosis by TUNEL assay. Original magnification, ×200. (B) Quantitation of CD31 vessel staining, Ki-67 staining, and TUNEL staining from immunohistochemical analyses are shown. Results are the mean ± S.E. of 20 sections per group. *
P < 0.05, **
P < 0.01, ***
P < 0.001 versus vehicle-treated animals.