A comparison of survival outcomes and side effects of toremifene or tamoxifen therapy in premenopausal estrogen and progesterone receptor positive breast cancer patients: a retrospective cohort study

Table 1 Definition of risk categories for breast cancer patients who had undergone surgery, according to the 2005 St. Gallen guidelines

Risk Category	Patient Features
Low risk	Node negative AND all of the following features:
	pT ≤2 cm,
	Grade 1,
	Absence of peritumoral vascular invasion,
	HER2/neu gene neither overexpressed nor amplified,
	Age ≥35 years
Intermediate risk	Node negative AND at least one of the following features:
	pT >2 cm,
	Grade 2–3,
	Presence of peritumoral vascular invasion,
	HER2/neu gene overexpressed or amplified,
	Age >35 years
	Node positive (1–3 involved nodes) AND
	HER2/neu gene neither overexpressed nor amplified
High risk	Node positive (1–3 involved nodes) AND
	HER2/neu gene overexpressed or amplified
	Node positive (4 or more involved nodes)

ISSN: 1471-2407