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Table 6 Joint effect between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of oropharyngeal cancer stratified by age

From: Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

HPV16 Serology

Genotypes

Age ≤ 58

Age > 58

Adjusted OR (95% CI) a

Patients (n = 116)

Controls (n = 145)

Patients (n = 68)

Controls (n = 170)

Age ≤ 58

Age > 58

 

NOXA rs9957673

      

-

CC (Ref.)

39

89

29

100

1.0

1.0

-

CT + TT

15

38

16

47

0.9 (0.5-2.0)

1.2 (0.6-2.5)

+

CC

36

14

14

13

6.4 (3.0-13.6)

4.0 (1.7-9.8)

+

CT + TT

26

4

9

10

14.9 (4.7-46.6)

3.6 (1.3-10.0)

      

P trend < 0.001

P trend = 0.077

 

NOXA rs4558496

      

-

TT (Ref.)

36

90

30

98

1.0

1.0

-

TG + GG

18

37

15

49

1.2 (0.6-2.4)

1.0 (0.5-2.1)

+

TT

38

11

17

17

9.5 (4.2-21.2)

3.5 (1.6-7.9)

+

TG + GG

24

7

6

6

8.2 (3.2-21.3)

3.9 (1.1-13.8)

      

P trend < 0.001

P trend = 0.222

 

MCL1 rs9803935

      

-

GG + GT (Ref.)

44

102

37

113

1.0

1.0

-

TT

10

25

8

34

0.9 (0.4-2.0)

0.8 (0.3-1.8)

+

GG + GT

42

17

19

20

5.9 (3.0 -11.8)

3.3 (1.6-8.0)

+

TT

20

1

4

3

47.2 (6.1 -368.2)

3.9 (0.8-19.0)

      

P trend < 0.001

P trend = 0.338

 

MCL1 rs3738485

      

-

GG + GC (Ref.)

44

100

37

112

1.0

1.0

-

CC

10

27

8

35

0.8 (0.4-1.9)

0.7 (0.3-1.7)

+

GG + GC

42

16

19

20

6.2 (3.1-12.5)

3.3 (1.5-7.0)

+

CC

20

2

4

3

22.7 (5.0-103.5)

3.8 (0.8-18.7)

      

P trend < 0.001

P trend = 0.270

  1. a ORs were adjusted for age, sex, tobacco smoking and alcohol drinking.