HPV16 Serology | Genotypes | Age ≤ 58 | Age > 58 | Adjusted OR (95% CI) a | |||
---|---|---|---|---|---|---|---|
Patients (n = 116) | Controls (n = 145) | Patients (n = 68) | Controls (n = 170) | Age ≤ 58 | Age > 58 | ||
 | NOXA rs9957673 |  |  |  |  |  |  |
- | CC (Ref.) | 39 | 89 | 29 | 100 | 1.0 | 1.0 |
- | CT + TT | 15 | 38 | 16 | 47 | 0.9 (0.5-2.0) | 1.2 (0.6-2.5) |
+ | CC | 36 | 14 | 14 | 13 | 6.4 (3.0-13.6) | 4.0 (1.7-9.8) |
+ | CT + TT | 26 | 4 | 9 | 10 | 14.9 (4.7-46.6) | 3.6 (1.3-10.0) |
 |  |  |  |  |  | P trend < 0.001 | P trend = 0.077 |
 | NOXA rs4558496 |  |  |  |  |  |  |
- | TT (Ref.) | 36 | 90 | 30 | 98 | 1.0 | 1.0 |
- | TG + GG | 18 | 37 | 15 | 49 | 1.2 (0.6-2.4) | 1.0 (0.5-2.1) |
+ | TT | 38 | 11 | 17 | 17 | 9.5 (4.2-21.2) | 3.5 (1.6-7.9) |
+ | TG + GG | 24 | 7 | 6 | 6 | 8.2 (3.2-21.3) | 3.9 (1.1-13.8) |
 |  |  |  |  |  | P trend < 0.001 | P trend = 0.222 |
 | MCL1 rs9803935 |  |  |  |  |  |  |
- | GG + GT (Ref.) | 44 | 102 | 37 | 113 | 1.0 | 1.0 |
- | TT | 10 | 25 | 8 | 34 | 0.9 (0.4-2.0) | 0.8 (0.3-1.8) |
+ | GG + GT | 42 | 17 | 19 | 20 | 5.9 (3.0 -11.8) | 3.3 (1.6-8.0) |
+ | TT | 20 | 1 | 4 | 3 | 47.2 (6.1 -368.2) | 3.9 (0.8-19.0) |
 |  |  |  |  |  | P trend < 0.001 | P trend = 0.338 |
 | MCL1 rs3738485 |  |  |  |  |  |  |
- | GG + GC (Ref.) | 44 | 100 | 37 | 112 | 1.0 | 1.0 |
- | CC | 10 | 27 | 8 | 35 | 0.8 (0.4-1.9) | 0.7 (0.3-1.7) |
+ | GG + GC | 42 | 16 | 19 | 20 | 6.2 (3.1-12.5) | 3.3 (1.5-7.0) |
+ | CC | 20 | 2 | 4 | 3 | 22.7 (5.0-103.5) | 3.8 (0.8-18.7) |
 |  |  |  |  |  | P trend < 0.001 | P trend = 0.270 |