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Table 6 Joint effect between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of oropharyngeal cancer stratified by age

From: Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

HPV16 Serology Genotypes Age ≤ 58 Age > 58 Adjusted OR (95% CI) a
Patients (n = 116) Controls (n = 145) Patients (n = 68) Controls (n = 170) Age ≤ 58 Age > 58
  NOXA rs9957673       
- CC (Ref.) 39 89 29 100 1.0 1.0
- CT + TT 15 38 16 47 0.9 (0.5-2.0) 1.2 (0.6-2.5)
+ CC 36 14 14 13 6.4 (3.0-13.6) 4.0 (1.7-9.8)
+ CT + TT 26 4 9 10 14.9 (4.7-46.6) 3.6 (1.3-10.0)
       P trend < 0.001 P trend = 0.077
  NOXA rs4558496       
- TT (Ref.) 36 90 30 98 1.0 1.0
- TG + GG 18 37 15 49 1.2 (0.6-2.4) 1.0 (0.5-2.1)
+ TT 38 11 17 17 9.5 (4.2-21.2) 3.5 (1.6-7.9)
+ TG + GG 24 7 6 6 8.2 (3.2-21.3) 3.9 (1.1-13.8)
       P trend < 0.001 P trend = 0.222
  MCL1 rs9803935       
- GG + GT (Ref.) 44 102 37 113 1.0 1.0
- TT 10 25 8 34 0.9 (0.4-2.0) 0.8 (0.3-1.8)
+ GG + GT 42 17 19 20 5.9 (3.0 -11.8) 3.3 (1.6-8.0)
+ TT 20 1 4 3 47.2 (6.1 -368.2) 3.9 (0.8-19.0)
       P trend < 0.001 P trend = 0.338
  MCL1 rs3738485       
- GG + GC (Ref.) 44 100 37 112 1.0 1.0
- CC 10 27 8 35 0.8 (0.4-1.9) 0.7 (0.3-1.7)
+ GG + GC 42 16 19 20 6.2 (3.1-12.5) 3.3 (1.5-7.0)
+ CC 20 2 4 3 22.7 (5.0-103.5) 3.8 (0.8-18.7)
       P trend < 0.001 P trend = 0.270
  1. a ORs were adjusted for age, sex, tobacco smoking and alcohol drinking.