|
HPV16 Serology
|
Genotypes
|
Never drinkers
|
Ever drinkers
|
Adjusted OR (95% CI) a
|
|---|
|
Patients (n = 36)
|
Controls (n = 90)
|
Patients (n = 148)
|
Controls (n = 225)
|
Never drinkers
|
Ever drinkers
|
|---|
| |
NOXA rs9957673
| | | | | | |
|
-
|
CC (Ref.)
|
14
|
57
|
54
|
132
|
1.0
|
1.0
|
|
-
|
CT + TT
|
3
|
24
|
28
|
61
|
0.5 (0.1-1.8)
|
1.2 (0.7-2.0)
|
|
+
|
CC
|
9
|
5
|
41
|
22
|
8.1 (2.2-29.5)
|
4.3 (2.3-8.0)
|
|
+
|
CT + TT
|
10
|
4
|
25
|
10
|
12.7 (3.2-50.0)
|
5.9 (2.6-13.3)
|
| | | | | | |
P
trend = 0.015
|
P
trend = 0.001
|
| |
NOXA rs4558496
| | | | | | |
|
-
|
TT (Ref.)
|
9
|
56
|
57
|
132
|
1.0
|
1.0
|
|
-
|
TG + GG
|
8
|
25
|
25
|
61
|
1.8 (0.6-5.4)
|
1.0 (0.6-1.7)
|
|
+
|
TT
|
16
|
7
|
39
|
21
|
15.4 (4.8-49.2)
|
4.1 (2.2-7.7)
|
|
+
|
TG + GG
|
3
|
2
|
27
|
11
|
12.9 (1.7-99.5)
|
5.4 (2.5-11.6)
|
| | | | | | |
P
trend = 0.019
|
P
trend = 0.001
|
| |
MCL1 rs9803935
| | | | | | |
|
-
|
GG + GT (Ref.)
|
12
|
65
|
69
|
150
|
1.0
|
1.0
|
|
-
|
TT
|
5
|
16
|
13
|
43
|
1.8 (0.5-5.8)
|
0.7 (0.3-1.4)
|
|
+
|
GG + GT
|
16
|
9
|
45
|
28
|
11.7 (3.9-34.7)
|
3.3 (1.9-5.8)
|
|
+
|
TT
|
3
|
NA
|
21
|
4
|
NA
|
10.8 (3.5-33.0)
|
| | | | | | |
P
trend = 0.002
|
P
trend = 0.001
|
| |
MCL1 rs3738485
| | | | | | |
|
-
|
GG + GC (Ref.)
|
12
|
63
|
69
|
149
|
1.0
|
1.0
|
|
-
|
CC
|
5
|
18
|
13
|
44
|
1.6 (0.5-5.1)
|
0.7 (0.3-1.3)
|
|
+
|
GG + GC
|
16
|
9
|
45
|
27
|
11.4 (3.8-34.1)
|
3.4 (1.9-6.0)
|
|
+
|
CC
|
3
|
NA
|
21
|
5
|
NA
|
8.6 (3.1-23.9)
|
| | | | | | |
P
trend = 0.760
|
P
trend = 0.001
|
-
a ORs were adjusted for age, sex, and tobacco smoking.
