Table 5 Joint effect between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of oropharyngeal cancer stratified by drinking status
HPV16 Serology | Genotypes | Never drinkers | Ever drinkers | Adjusted OR (95% CI) a | |||
|---|---|---|---|---|---|---|---|
Patients (n = 36) | Controls (n = 90) | Patients (n = 148) | Controls (n = 225) | Never drinkers | Ever drinkers | ||
| Â | NOXA rs9957673 | Â | Â | Â | Â | Â | Â |
- | CC (Ref.) | 14 | 57 | 54 | 132 | 1.0 | 1.0 |
- | CT + TT | 3 | 24 | 28 | 61 | 0.5 (0.1-1.8) | 1.2 (0.7-2.0) |
+ | CC | 9 | 5 | 41 | 22 | 8.1 (2.2-29.5) | 4.3 (2.3-8.0) |
+ | CT + TT | 10 | 4 | 25 | 10 | 12.7 (3.2-50.0) | 5.9 (2.6-13.3) |
|  |  |  |  |  |  | P trend = 0.015 | P trend = 0.001 |
| Â | NOXA rs4558496 | Â | Â | Â | Â | Â | Â |
- | TT (Ref.) | 9 | 56 | 57 | 132 | 1.0 | 1.0 |
- | TG + GG | 8 | 25 | 25 | 61 | 1.8 (0.6-5.4) | 1.0 (0.6-1.7) |
+ | TT | 16 | 7 | 39 | 21 | 15.4 (4.8-49.2) | 4.1 (2.2-7.7) |
+ | TG + GG | 3 | 2 | 27 | 11 | 12.9 (1.7-99.5) | 5.4 (2.5-11.6) |
|  |  |  |  |  |  | P trend = 0.019 | P trend = 0.001 |
| Â | MCL1 rs9803935 | Â | Â | Â | Â | Â | Â |
- | GG + GT (Ref.) | 12 | 65 | 69 | 150 | 1.0 | 1.0 |
- | TT | 5 | 16 | 13 | 43 | 1.8 (0.5-5.8) | 0.7 (0.3-1.4) |
+ | GG + GT | 16 | 9 | 45 | 28 | 11.7 (3.9-34.7) | 3.3 (1.9-5.8) |
+ | TT | 3 | NA | 21 | 4 | NA | 10.8 (3.5-33.0) |
|  |  |  |  |  |  | P trend = 0.002 | P trend = 0.001 |
| Â | MCL1 rs3738485 | Â | Â | Â | Â | Â | Â |
- | GG + GC (Ref.) | 12 | 63 | 69 | 149 | 1.0 | 1.0 |
- | CC | 5 | 18 | 13 | 44 | 1.6 (0.5-5.1) | 0.7 (0.3-1.3) |
+ | GG + GC | 16 | 9 | 45 | 27 | 11.4 (3.8-34.1) | 3.4 (1.9-6.0) |
+ | CC | 3 | NA | 21 | 5 | NA | 8.6 (3.1-23.9) |
|  |  |  |  |  |  | P trend = 0.760 | P trend = 0.001 |