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Table 5 Joint effect between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of oropharyngeal cancer stratified by drinking status

From: Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

HPV16 Serology Genotypes Never drinkers Ever drinkers Adjusted OR (95% CI) a
Patients (n = 36) Controls (n = 90) Patients (n = 148) Controls (n = 225) Never drinkers Ever drinkers
  NOXA rs9957673       
- CC (Ref.) 14 57 54 132 1.0 1.0
- CT + TT 3 24 28 61 0.5 (0.1-1.8) 1.2 (0.7-2.0)
+ CC 9 5 41 22 8.1 (2.2-29.5) 4.3 (2.3-8.0)
+ CT + TT 10 4 25 10 12.7 (3.2-50.0) 5.9 (2.6-13.3)
       P trend = 0.015 P trend = 0.001
  NOXA rs4558496       
- TT (Ref.) 9 56 57 132 1.0 1.0
- TG + GG 8 25 25 61 1.8 (0.6-5.4) 1.0 (0.6-1.7)
+ TT 16 7 39 21 15.4 (4.8-49.2) 4.1 (2.2-7.7)
+ TG + GG 3 2 27 11 12.9 (1.7-99.5) 5.4 (2.5-11.6)
       P trend = 0.019 P trend = 0.001
  MCL1 rs9803935       
- GG + GT (Ref.) 12 65 69 150 1.0 1.0
- TT 5 16 13 43 1.8 (0.5-5.8) 0.7 (0.3-1.4)
+ GG + GT 16 9 45 28 11.7 (3.9-34.7) 3.3 (1.9-5.8)
+ TT 3 NA 21 4 NA 10.8 (3.5-33.0)
       P trend = 0.002 P trend = 0.001
  MCL1 rs3738485       
- GG + GC (Ref.) 12 63 69 149 1.0 1.0
- CC 5 18 13 44 1.6 (0.5-5.1) 0.7 (0.3-1.3)
+ GG + GC 16 9 45 27 11.4 (3.8-34.1) 3.4 (1.9-6.0)
+ CC 3 NA 21 5 NA 8.6 (3.1-23.9)
       P trend = 0.760 P trend = 0.001
  1. a ORs were adjusted for age, sex, and tobacco smoking.