|
HPV16 Serology
|
Genotypes
|
Never smokers
|
Ever smokers
|
Adjusted OR (95% CI) a
|
|---|
|
Patients (n = 61)
|
Controls (n = 90)
|
Patients (n = 123)
|
Controls (n = 225)
|
Never smokers
|
Ever smokers
|
|---|
| |
NOXA rs9957673
| | | | | | |
|
-
|
CC (Ref.)
|
19
|
52
|
49
|
137
|
1.0
|
1.0
|
|
-
|
CT + TT
|
7
|
30
|
24
|
55
|
0.7 (0.2-1.8)
|
1.2 (0.7-2.2)
|
|
+
|
CC
|
18
|
7
|
32
|
20
|
8.3 (2.8-24.9)
|
4.3 (2.4-8.4)
|
|
+
|
CT + TT
|
17
|
1
|
18
|
13
|
50.6 (6.1-422.0)
|
4.1 (1.9-9.2)
|
| | | | | | |
P
trend = 0.001
|
P
trend = 0.004
|
| |
NOXA rs4558496
| | | | | | |
|
-
|
TT (Ref.)
|
19
|
57
|
47
|
131
|
1.0
|
1.0
|
|
-
|
TG + GG
|
7
|
25
|
26
|
61
|
0.7 (0.2-2.0)
|
1.2 (0.7-2.1)
|
|
+
|
TT
|
26
|
7
|
29
|
21
|
13.4 (4.7-37.8)
|
4.0 (2.0-7.7)
|
|
+
|
TG + GG
|
9
|
1
|
21
|
12
|
21.9 (2.5-192.6)
|
4.7 (2.1-10.5)
|
| | | | | | |
P
trend = 0.008
|
P
trend = 0.002
|
| |
MCL1 rs3738485
| | | | | | |
|
-
|
GG + GT (Ref.)
|
20
|
66
|
61
|
149
|
1.0
|
1.0
|
|
-
|
TT
|
6
|
16
|
12
|
43
|
1.4 (0.5-4.3)
|
0.7 (0.3-1.4)
|
|
+
|
GG + GT
|
27
|
7
|
34
|
30
|
15.4 (5.5-43.6)
|
2.8 (1.6-5.1)
|
|
+
|
TT
|
8
|
1
|
16
|
3
|
28.0 (3.2-246.6)
|
12.1 (3.4-43.3)
|
| | | | | | |
P
trend < 0.001
|
P
trend = 0.003
|
| |
MCL1 rs3738485
| | | | | | |
|
-
|
GG + GC (Ref.)
|
20
|
65
|
61
|
147
|
1.0
|
1.0
|
|
-
|
CC
|
6
|
17
|
12
|
45
|
1.3 (0.4-4.1)
|
0.6 (0.3-1.3)
|
|
+
|
GG + GC
|
27
|
7
|
34
|
29
|
15.3 (5.4-43.5)
|
2.9 (1.6-5.2)
|
|
+
|
CC
|
8
|
1
|
16
|
4
|
27.7 (3.1-244.7)
|
8.8 (2.8-27.8)
|
| | | | | | |
P
trend < 0.001
|
P
trend = 0.008
|
-
a ORs were adjusted for age, sex, and alcohol drinking.
