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Table 4 Joint effect between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of oropharyngeal cancer stratified by smoking status

From: Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

HPV16 Serology Genotypes Never smokers Ever smokers Adjusted OR (95% CI) a
Patients (n = 61) Controls (n = 90) Patients (n = 123) Controls (n = 225) Never smokers Ever smokers
  NOXA rs9957673       
- CC (Ref.) 19 52 49 137 1.0 1.0
- CT + TT 7 30 24 55 0.7 (0.2-1.8) 1.2 (0.7-2.2)
+ CC 18 7 32 20 8.3 (2.8-24.9) 4.3 (2.4-8.4)
+ CT + TT 17 1 18 13 50.6 (6.1-422.0) 4.1 (1.9-9.2)
       P trend = 0.001 P trend = 0.004
  NOXA rs4558496       
- TT (Ref.) 19 57 47 131 1.0 1.0
- TG + GG 7 25 26 61 0.7 (0.2-2.0) 1.2 (0.7-2.1)
+ TT 26 7 29 21 13.4 (4.7-37.8) 4.0 (2.0-7.7)
+ TG + GG 9 1 21 12 21.9 (2.5-192.6) 4.7 (2.1-10.5)
       P trend = 0.008 P trend = 0.002
  MCL1 rs3738485       
- GG + GT (Ref.) 20 66 61 149 1.0 1.0
- TT 6 16 12 43 1.4 (0.5-4.3) 0.7 (0.3-1.4)
+ GG + GT 27 7 34 30 15.4 (5.5-43.6) 2.8 (1.6-5.1)
+ TT 8 1 16 3 28.0 (3.2-246.6) 12.1 (3.4-43.3)
       P trend < 0.001 P trend = 0.003
  MCL1 rs3738485       
- GG + GC (Ref.) 20 65 61 147 1.0 1.0
- CC 6 17 12 45 1.3 (0.4-4.1) 0.6 (0.3-1.3)
+ GG + GC 27 7 34 29 15.3 (5.4-43.5) 2.9 (1.6-5.2)
+ CC 8 1 16 4 27.7 (3.1-244.7) 8.8 (2.8-27.8)
       P trend < 0.001 P trend = 0.008
  1. a ORs were adjusted for age, sex, and alcohol drinking.