Table 4 Joint effect between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of oropharyngeal cancer stratified by smoking status
HPV16 Serology | Genotypes | Never smokers | Ever smokers | Adjusted OR (95% CI) a | |||
|---|---|---|---|---|---|---|---|
Patients (n = 61) | Controls (n = 90) | Patients (n = 123) | Controls (n = 225) | Never smokers | Ever smokers | ||
| Â | NOXA rs9957673 | Â | Â | Â | Â | Â | Â |
- | CC (Ref.) | 19 | 52 | 49 | 137 | 1.0 | 1.0 |
- | CT + TT | 7 | 30 | 24 | 55 | 0.7 (0.2-1.8) | 1.2 (0.7-2.2) |
+ | CC | 18 | 7 | 32 | 20 | 8.3 (2.8-24.9) | 4.3 (2.4-8.4) |
+ | CT + TT | 17 | 1 | 18 | 13 | 50.6 (6.1-422.0) | 4.1 (1.9-9.2) |
|  |  |  |  |  |  | P trend = 0.001 | P trend = 0.004 |
| Â | NOXA rs4558496 | Â | Â | Â | Â | Â | Â |
- | TT (Ref.) | 19 | 57 | 47 | 131 | 1.0 | 1.0 |
- | TG + GG | 7 | 25 | 26 | 61 | 0.7 (0.2-2.0) | 1.2 (0.7-2.1) |
+ | TT | 26 | 7 | 29 | 21 | 13.4 (4.7-37.8) | 4.0 (2.0-7.7) |
+ | TG + GG | 9 | 1 | 21 | 12 | 21.9 (2.5-192.6) | 4.7 (2.1-10.5) |
|  |  |  |  |  |  | P trend = 0.008 | P trend = 0.002 |
| Â | MCL1 rs3738485 | Â | Â | Â | Â | Â | Â |
- | GG + GT (Ref.) | 20 | 66 | 61 | 149 | 1.0 | 1.0 |
- | TT | 6 | 16 | 12 | 43 | 1.4 (0.5-4.3) | 0.7 (0.3-1.4) |
+ | GG + GT | 27 | 7 | 34 | 30 | 15.4 (5.5-43.6) | 2.8 (1.6-5.1) |
+ | TT | 8 | 1 | 16 | 3 | 28.0 (3.2-246.6) | 12.1 (3.4-43.3) |
|  |  |  |  |  |  | P trend < 0.001 | P trend = 0.003 |
| Â | MCL1 rs3738485 | Â | Â | Â | Â | Â | Â |
- | GG + GC (Ref.) | 20 | 65 | 61 | 147 | 1.0 | 1.0 |
- | CC | 6 | 17 | 12 | 45 | 1.3 (0.4-4.1) | 0.6 (0.3-1.3) |
+ | GG + GC | 27 | 7 | 34 | 29 | 15.3 (5.4-43.5) | 2.9 (1.6-5.2) |
+ | CC | 8 | 1 | 16 | 4 | 27.7 (3.1-244.7) | 8.8 (2.8-27.8) |
|  |  |  |  |  |  | P trend < 0.001 | P trend = 0.008 |