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Table 3 Joint effects between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of SCCHN

From: Genetic variants of NOXA and MCL1 modify the risk of HPV16-associated squamous cell carcinoma of the head and neck

HPV16 Serology Gene Variant Control Overall (n = 372) Oropharynx (n = 184) non-oropharynx (n = 188)
  n = 315 (%) Patients (%) ORa (95%CI) Patients (%) ORa (95%CI) Patients (%) ORa (95%CI)
  NOXA rs9957673        
- CC (Ref.) 189 (60.0) 187 (50.3) 1.0 68 (37.4) 1.0 119 (63.3) 1.0
- CT + TT 85 (27.0) 83 (22.3) 1.0 (0.7-1.4) 31 (17.0) 1.0 (0.6-1.7) 52 (27.7) 1.0 (0.7-1.5)
+ CC 27 (8.6) 59 (15.9) 2.4 (1.4-4.0) 50 (27.2) 4.8 (2.8-8.3) 9 (4.8) 0.5 (0.2-1.2)
+ CT + TT 14 (4.4) 43 (11.6) 3.6 (1.9-6.8) 35 (19.0) 7.1 (3.6-14.3) 8 (4.3) 1.1 (0.4-2.8)
     P trend =0.017   P trend < 0.001   P trend = 0.744
  NOXA rs4558496        
- TT (Ref.) 188 (59.7) 188 (50.8) 1.0 66 (36.3) 1.0 123 (65.4) 1.0
- TG + GG 86 (27.3) 86 (21.8) 0.9 (0.6-1.4) 33 (17.9) 1.1 (0.7-1.8) 48 (25.5) 0.8 (0.5-1.3)
+ TT 28 (8.9) 68 (18.3) 2.7 (1.7-4.5) 55 (29.9) 5.6 (3.2-9.6) 13 (6.9) 0.8 (0.4-1.7)
+ TG + GG 13 (4.1) 34 (9.1) 2.8 (1.4-5.5) 30 (16.3) 6.1 (3.0-12.6) 4 (2.1) 0.4 (0.1-1.4)
     P trend =0.086   P trend < 0.001   P trend = 0.197
  MCL1 rs9803935        
- GG + GT (Ref.) 215 (68.2) 224 (60.2) 1.0 81 (44.0) 1.0 143 (76.1) 1.0
- TT 59 (18.7) 46 (12.4) 0.8 (0.5-1.2) 18 (9.8) 0.8 (0.5-1.5) 28 (14.9) 0.8 (0.5-1.3)
+ GG + GT 37 (11.8) 72 (19.4) 2.1 (1.3-3.3) 61 (33.2) 4.3 (2.6-7.1) 11 (5.9) 0.5 (0.2-1.0)
+ TT 4 (1.3) 30 (8.1) 8.1 (2.8-23.7) 24 (13.0) 14.9 (5.0-44.6) 6 (3.2) 2.7 (0.7-9.8)
     P trend =0.030   P trend < 0.001   P trend = 0.317
  MCL1 rs3738485        
- GG + GC (Ref.) 212 (67.3) 223 (60.0) 1.0 81 (44.0) 1.0 142 (75.5) 1.0
- CC 62 (19.7) 47 (12.6) 0.8 (0.5-1.2) 18 (9.8) 0.8 (0.4-1.4) 29 (15.4) 0.8 (0.5-1.3)
+ GG + GC 36 (11.4) 73 (19.6) 2.2 (1.4-3.4) 61 (33.2) 4.4 (2.7-7.2) 12 (6.4) 0.5 (0.3-1.1)
+ CC 5 (1.6) 29 (7.8) 6.3 (2.4-16.7) 24 (13.0) 11.7 (4.3-32.0) 5 (2.7) 1.9 (0.5-6.8)
     P trend =0.071   P trend < 0.001   P trend = 0.189
  1. a ORs were adjusted for age, sex, and tobacco smoking and alcohol drinking.
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