HPV16 Serology
|
Gene Variant
|
Control
|
Overall (n = 372)
|
Oropharynx (n = 184)
|
non-oropharynx (n = 188)
|
---|
|
n = 315 (%)
|
Patients (%)
|
ORa (95%CI)
|
Patients (%)
|
ORa (95%CI)
|
Patients (%)
|
ORa (95%CI)
|
---|
|
NOXA rs9957673
| | | | | | | |
-
|
CC (Ref.)
|
189 (60.0)
|
187 (50.3)
|
1.0
|
68 (37.4)
|
1.0
|
119 (63.3)
|
1.0
|
-
|
CT + TT
|
85 (27.0)
|
83 (22.3)
|
1.0 (0.7-1.4)
|
31 (17.0)
|
1.0 (0.6-1.7)
|
52 (27.7)
|
1.0 (0.7-1.5)
|
+
|
CC
|
27 (8.6)
|
59 (15.9)
|
2.4 (1.4-4.0)
|
50 (27.2)
|
4.8 (2.8-8.3)
|
9 (4.8)
|
0.5 (0.2-1.2)
|
+
|
CT + TT
|
14 (4.4)
|
43 (11.6)
|
3.6 (1.9-6.8)
|
35 (19.0)
|
7.1 (3.6-14.3)
|
8 (4.3)
|
1.1 (0.4-2.8)
|
| | | |
P
trend =0.017
| |
P
trend < 0.001
| |
P
trend = 0.744
|
|
NOXA rs4558496
| | | | | | | |
-
|
TT (Ref.)
|
188 (59.7)
|
188 (50.8)
|
1.0
|
66 (36.3)
|
1.0
|
123 (65.4)
|
1.0
|
-
|
TG + GG
|
86 (27.3)
|
86 (21.8)
|
0.9 (0.6-1.4)
|
33 (17.9)
|
1.1 (0.7-1.8)
|
48 (25.5)
|
0.8 (0.5-1.3)
|
+
|
TT
|
28 (8.9)
|
68 (18.3)
|
2.7 (1.7-4.5)
|
55 (29.9)
|
5.6 (3.2-9.6)
|
13 (6.9)
|
0.8 (0.4-1.7)
|
+
|
TG + GG
|
13 (4.1)
|
34 (9.1)
|
2.8 (1.4-5.5)
|
30 (16.3)
|
6.1 (3.0-12.6)
|
4 (2.1)
|
0.4 (0.1-1.4)
|
| | | |
P
trend =0.086
| |
P
trend < 0.001
| |
P
trend = 0.197
|
|
MCL1 rs9803935
| | | | | | | |
-
|
GG + GT (Ref.)
|
215 (68.2)
|
224 (60.2)
|
1.0
|
81 (44.0)
|
1.0
|
143 (76.1)
|
1.0
|
-
|
TT
|
59 (18.7)
|
46 (12.4)
|
0.8 (0.5-1.2)
|
18 (9.8)
|
0.8 (0.5-1.5)
|
28 (14.9)
|
0.8 (0.5-1.3)
|
+
|
GG + GT
|
37 (11.8)
|
72 (19.4)
|
2.1 (1.3-3.3)
|
61 (33.2)
|
4.3 (2.6-7.1)
|
11 (5.9)
|
0.5 (0.2-1.0)
|
+
|
TT
|
4 (1.3)
|
30 (8.1)
|
8.1 (2.8-23.7)
|
24 (13.0)
|
14.9 (5.0-44.6)
|
6 (3.2)
|
2.7 (0.7-9.8)
|
| | | |
P
trend =0.030
| |
P
trend < 0.001
| |
P
trend = 0.317
|
|
MCL1 rs3738485
| | | | | | | |
-
|
GG + GC (Ref.)
|
212 (67.3)
|
223 (60.0)
|
1.0
|
81 (44.0)
|
1.0
|
142 (75.5)
|
1.0
|
-
|
CC
|
62 (19.7)
|
47 (12.6)
|
0.8 (0.5-1.2)
|
18 (9.8)
|
0.8 (0.4-1.4)
|
29 (15.4)
|
0.8 (0.5-1.3)
|
+
|
GG + GC
|
36 (11.4)
|
73 (19.6)
|
2.2 (1.4-3.4)
|
61 (33.2)
|
4.4 (2.7-7.2)
|
12 (6.4)
|
0.5 (0.3-1.1)
|
+
|
CC
|
5 (1.6)
|
29 (7.8)
|
6.3 (2.4-16.7)
|
24 (13.0)
|
11.7 (4.3-32.0)
|
5 (2.7)
|
1.9 (0.5-6.8)
|
| | | |
P
trend =0.071
| |
P
trend < 0.001
| |
P
trend = 0.189
|
-
a ORs were adjusted for age, sex, and tobacco smoking and alcohol drinking.