Table 3 Joint effects between HPV16 seropositivity and NOXA and MCL1 genotypes on risk of SCCHN
HPV16 Serology | Gene Variant | Control | Overall (n = 372) | Oropharynx (n = 184) | non-oropharynx (n = 188) | |||
|---|---|---|---|---|---|---|---|---|
|  | n = 315 (%) | Patients (%) | ORa (95%CI) | Patients (%) | ORa (95%CI) | Patients (%) | ORa (95%CI) | |
| Â | NOXA rs9957673 | Â | Â | Â | Â | Â | Â | Â |
- | CC (Ref.) | 189 (60.0) | 187 (50.3) | 1.0 | 68 (37.4) | 1.0 | 119 (63.3) | 1.0 |
- | CT + TT | 85 (27.0) | 83 (22.3) | 1.0 (0.7-1.4) | 31 (17.0) | 1.0 (0.6-1.7) | 52 (27.7) | 1.0 (0.7-1.5) |
+ | CC | 27 (8.6) | 59 (15.9) | 2.4 (1.4-4.0) | 50 (27.2) | 4.8 (2.8-8.3) | 9 (4.8) | 0.5 (0.2-1.2) |
+ | CT + TT | 14 (4.4) | 43 (11.6) | 3.6 (1.9-6.8) | 35 (19.0) | 7.1 (3.6-14.3) | 8 (4.3) | 1.1 (0.4-2.8) |
|  |  |  |  | P trend =0.017 |  | P trend < 0.001 |  | P trend = 0.744 |
| Â | NOXA rs4558496 | Â | Â | Â | Â | Â | Â | Â |
- | TT (Ref.) | 188 (59.7) | 188 (50.8) | 1.0 | 66 (36.3) | 1.0 | 123 (65.4) | 1.0 |
- | TG + GG | 86 (27.3) | 86 (21.8) | 0.9 (0.6-1.4) | 33 (17.9) | 1.1 (0.7-1.8) | 48 (25.5) | 0.8 (0.5-1.3) |
+ | TT | 28 (8.9) | 68 (18.3) | 2.7 (1.7-4.5) | 55 (29.9) | 5.6 (3.2-9.6) | 13 (6.9) | 0.8 (0.4-1.7) |
+ | TG + GG | 13 (4.1) | 34 (9.1) | 2.8 (1.4-5.5) | 30 (16.3) | 6.1 (3.0-12.6) | 4 (2.1) | 0.4 (0.1-1.4) |
|  |  |  |  | P trend =0.086 |  | P trend < 0.001 |  | P trend = 0.197 |
| Â | MCL1 rs9803935 | Â | Â | Â | Â | Â | Â | Â |
- | GG + GT (Ref.) | 215 (68.2) | 224 (60.2) | 1.0 | 81 (44.0) | 1.0 | 143 (76.1) | 1.0 |
- | TT | 59 (18.7) | 46 (12.4) | 0.8 (0.5-1.2) | 18 (9.8) | 0.8 (0.5-1.5) | 28 (14.9) | 0.8 (0.5-1.3) |
+ | GG + GT | 37 (11.8) | 72 (19.4) | 2.1 (1.3-3.3) | 61 (33.2) | 4.3 (2.6-7.1) | 11 (5.9) | 0.5 (0.2-1.0) |
+ | TT | 4 (1.3) | 30 (8.1) | 8.1 (2.8-23.7) | 24 (13.0) | 14.9 (5.0-44.6) | 6 (3.2) | 2.7 (0.7-9.8) |
|  |  |  |  | P trend =0.030 |  | P trend < 0.001 |  | P trend = 0.317 |
| Â | MCL1 rs3738485 | Â | Â | Â | Â | Â | Â | Â |
- | GG + GC (Ref.) | 212 (67.3) | 223 (60.0) | 1.0 | 81 (44.0) | 1.0 | 142 (75.5) | 1.0 |
- | CC | 62 (19.7) | 47 (12.6) | 0.8 (0.5-1.2) | 18 (9.8) | 0.8 (0.4-1.4) | 29 (15.4) | 0.8 (0.5-1.3) |
+ | GG + GC | 36 (11.4) | 73 (19.6) | 2.2 (1.4-3.4) | 61 (33.2) | 4.4 (2.7-7.2) | 12 (6.4) | 0.5 (0.3-1.1) |
+ | CC | 5 (1.6) | 29 (7.8) | 6.3 (2.4-16.7) | 24 (13.0) | 11.7 (4.3-32.0) | 5 (2.7) | 1.9 (0.5-6.8) |
|  |  |  |  | P trend =0.071 |  | P trend < 0.001 |  | P trend = 0.189 |