Body mass index and survival after breast cancer diagnosis in Japanese women

BMC Cancer

Table 4 HR (95%CI) of all-cause and breast cancer-specific death associated with BMI by hormone receptor status

		BMI	Patients	Person-years	All-cause death				Breast cancer-specific death
					Number of death	HR ^a	95% CI		Number of death	HR ^a	95% CI
ER + or PgR+
		<21.2	96	581.5	18	2.91	1.09 - 7.77		16	7.23	1.57 - 33.34
		≥21.2 to <23.3	96	612.5	6	1.00 (reference)			2	1.00 (reference)
		≥23.3 to <25.8	105	670.5	12	1.16	0.41 - 3.24		9	3.31	0.67 - 16.41
		≥25.8	113	708.9	21	2.49	0.96 - 6.47		12	4.95	1.05 - 23.35
	p for trend							0.85				0.57
	p for trend in women with BMI ≥21.2							0.02				0.031
ER-/PgR-
		<21.2	46	295.2	14	0.95	0.41 - 2.20		10	0.90	0.35 - 2.29
		≥21.2 to <23.3	50	350.7	12	1.00 (reference)			11	1.00 (reference)
		≥23.3 to <25.8	41	265.0	13	0.72	0.30 - 1.75		13	0.88	0.35 - 2.21
		≥25.8	37	241.9	11	0.94	0.38 - 2.33		9	1.00	0.38 - 2.64
	p for trend							0.77				0.91
	p for trend in women with BMI ≥21.2							0.96				0.98
ER + or PgR + v ER-/PgR- p for heterogeneity of trends								0.80				0.61
ER + or PgR + v ER-/PgR- p for heterogeneity of trends in women with BMI ≥21.2								0.10				0.13

^a Adjusted by age, stage (in situ or localized, lymph node metastasis, local invasion, distant metastasis, missing), radiation therapy (no, yes), chemotherapy (no, yes), endocrine therapy (no, yes), smoking (current, past, never, missing), family history of breast cancer in father, mother, brother or sister (no, yes), menopausal status (premenopausal, postmenopausal, missing), physical activity (almost no, more than one hour per week, missing) and comorbidities (no, yes).
Among women with ER + or PgR + tumors, BMI was significantly associated with both all-cause and breast cancer-specific death in those with BMI ≥21.2 kg/m², and lighter (BMI <21.2 kg/m²) women also had a higher risk of all-cause and breast cancer-specific death.

ISSN: 1471-2407