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Table 3 HR (95%CI) of breast cancer-specific death associated with BMI overall and by menopausal status

From: Body mass index and survival after breast cancer diagnosis in Japanese women

 

BMI

Patients

Person-years

Breast cancer- specific death

Age-adjusted

 

Multivariate-adjusted

 
      

HR

95% CI

 

HR

95% CI

 

All

  

<21.2

163

963.0

34

1.69

0.98 - 2.92

 

1.59

0.90 - 2.81

 
  

≥21.2 to <23.3

166

1052.4

21

1.00 (reference)

1.00 (reference) a

  

≥23.3 to <25.8

161

1020.1

26

1.32

0.74 - 2.35

 

1.20

0.66 - 2.17

 
  

≥25.8

163

997.3

27

1.40

0.79 - 2.49

 

1.46

0.81 - 2.64

 
 

p for trend

  

0.64

  

0.87

 

p for trend in women with BMI ≥21.2

  

0.20

  

0.18

Premenopausal

  

<21.2

89

556.1

15

1.60

0.68 - 3.80

 

1.22

0.47 - 3.14

 
  

≥21.2 to <23.3

73

510.2

8

1.00 (reference)

 

1.00 (reference) b

 
  

≥23.3 to <25.8

63

391.6

11

1.77

0.71 - 4.41

 

1.62

0.63 - 4.20

 
  

≥25.8

52

319.8

10

1.95

0.77 - 4.96

 

1.68

0.61 - 4.65

 
 

p for trend

  

0.48

  

0.34

 

p for trend in women with BMI ≥21.2

  

0.18

  

0.51

Postmenopausal

  

<21.2

67

371.6

15

1.89

0.87 - 4.11

 

1.22

0.52 - 2.86

 
  

≥21.2 to <23.3

86

500.7

11

1.00 (reference)

 

1.00 (reference) b

 
  

≥23.3 to <25.8

93

589.2

13

1.09

0.49 - 2.45

 

0.79

0.32 - 1.93

 
  

≥25.8

108

670.7

14

1.02

0.46 - 2.26

 

1.03

0.43 - 2.50

 
 

p for trend

  

0.15

  

0.56

 

p for trend in women with BMI ≥21.2

  

0.86

  

0.45

Pre v Post p for heterogeneity of trends

  

0.13

  

0.27

Pre v Post p for heterogeneity of trends in women with BMI ≥21.2

 

0.29

  

0.80

  1. a Adjusted by age, stage (in situ or localized, lymph node metastasis, local invasion, distant metastasis, missing), hormone receptor (ER + or PgR+, ER-/PgR-, Missing), radiation therapy (no, yes), chemotherapy (no, yes), endocrine therapy (no, yes), smoking (current, past, never, missing), family history of breast cancer in father, mother, brother or sister (no, yes), menopausal status (premenopausal, postmenopausal, missing), physical activity (almost no, more than one hour per week, missing) and comorbidities (no, yes).
  2. b Adjusted by age, stage, hormone receptor, radiation therapy, chemotherapy, endocrine therapy, smoking, family history of breast cancer in father, mother, brother or sister, physical activity and comorbidities.
  3. No dose–response relationship between BMI and breast cancer-specific death was found.