Table 2 Gene ontology analysis of genes affected by combined genistein and vorinostat treatment using DAVID knowledgebase (columns 1–4) and ingenuity knowledgebase (columns 5–7)
GO Term | Biological Process | Count | p-value | IPA Biological Function | Count | p-value |
|---|---|---|---|---|---|---|
GO:0006281 | DNA repair | 45 | 1.03E-13 | DNA Replication, Recombination, and Repair | 39 | 7.18E-12 |
GO:0008219 | Cell Death | 48 | 2.73E-03 | Cell Death | 122 | 1.95E-10 |
GO:0022403 | Cell Cycle | 57 | 1.63E-14 | Cell Cycle | 105 | 2.70E-09 |
GO:0006915 | Apoptosis | 43 | 1.37E-03 | Apoptosis | 149 | 1.13E-07 |
GO:0000075 | Cell Cycle Checkpoint | 17 | 1.45E-06 | DNA checkpoint control | 13 | 1.90E-06 |
GO:0006325 | Chromatin Organization | 28 | 7.01E-03 | Binding Of Chromatin | 5 | 1.69E-03 |