Table 2 Correlations between ALCAM expression and clinicopathological factors
ALCAM expression | |||||
|---|---|---|---|---|---|
All patients | negative (IRS 0-1) | positive (IRS 2-12) | p-value | ||
All samples | 233 | 97 | 136 | ||
Histological subtype (n = 233) | squamous | 171 | 70 | 101 | |
adenomatous | 35 | 18 | 17 | ||
adenosquamous | 27 | 9 | 18 | 0.338 | |
FIGO stage (n = 233) | I | 143 | 60 | 83 | |
II | 65 | 25 | 40 | ||
III/IV | 25 | 12 | 13 | 0.971 | |
Nodal involvement (n = 233) | pN0 | 175 | 75 | 100 | |
pN1 | 58 | 22 | 36 | 0.542 | |
Number of Positive lymph nodes (n = 233) | 0 | 175 | 75 | 100 | |
1-3 | 39 | 12 | 27 | ||
> 3 | 19 | 10 | 9 | 0.229 | |
Tumor grade (n = 227) | G1 | 9 | 4 | 5 | |
G2 | 100 | 43 | 57 | ||
G3 | 118 | 46 | 72 | 0.788 | |
Lymphatic invasion (n = 207) | L0 | 68 | 33 | 35 | |
L1 | 139 | 55 | 84 | 0.234 | |
Invasion depth in mm (n = 195) | geometric mean | 14.2 | 14.3 (n = 90) | 14.1 (n = 105) | 0.856 |
Patients age in years (n = 233) | mean | 48.8 | 48.3 | 49.1 | 0.662 |
SCC-Ag in μg/L (n = 156) | geometric mean | 1.9 | 2.5 (n = 64) | 1.5 (n = 92) | 0.012 |
s-ALCAM in ng/mL (n = 55) | geometric mean | 28.3 | 29.0 (n = 21) | 27.8 (n = 34) | 0.515 |
Progression-free survival in months (PFS; n = 47) | median | 13 | 9 (n = 19) | 15 (n = 28) | 0.208 |