Table 4 Solicited Grade 3/4 toxicities (physician evaluation) by baseline KI and age group
n (%) of patients with maximum Grade 3/4 toxicity | |||||
|---|---|---|---|---|---|
Toxicity | All patients treated (N = 516) | Baseline KI ≥ 80% (N = 322) | Baseline KI < 80% (N = 193) | Age < 70 years (N = 329) | Age ≥ 70 years (N = 187) |
Any toxicity | 123 (23.8) | 56 (17.4) | 67 (34.7) | 87 (26.4) | 36 ( 19.3) |
Fatigue/asthenia | 82 (15.9) | 32 ( 9.9) | 50 (25.9) | 54 (16.4) | 28 ( 15.0) |
Neutropenia | 45 ( 8.7) | 21 ( 6.5) | 24 (12.4) | 30 ( 9.1) | 15 ( 8.0) |
Nausea | 16 ( 3.1) | 6 ( 1.9) | 10 ( 5.2) | 10 ( 3.0) | 6 ( 3.2) |
Febrile neutropenia | 10 ( 1.9) | 3 ( 0.9) | 7 ( 3.6) | 6 ( 1.8) | 4 ( 2.1) |
Rash/desquamation | 7 ( 1.4) | 6 ( 1.9) | 1 ( 0.5) | 4 ( 1.2) | 3 ( 1.6) |
Stomatitis/pharyngitis | 7 ( 1.4) | 3 ( 0.9) | 4 ( 2.1) | 3 ( 0.9) | 4 ( 2.1) |
Mucositis | 5 ( 1.0) | 1 ( 0.3) | 4 ( 2.1) | 3 ( 0.9) | 2 ( 1.1) |
Vomiting | 5 ( 1.0) | 2 ( 0.6) | 3 ( 1.6) | 4 ( 1.2) | 1 ( 0.5) |
Diarrhea | 2 ( 0.4) | 1 ( 0.3) | 1 ( 0.5) | 2 ( 0.6) | 0 ( 0.0) |