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Table 3 Genealogical Index of Familiality for cancers with at least 200 cases with genealogy data, ranked by empirical significance for overall excess relatedness (and ranked by case GIF where the overall empirical significance values are equivalent)

From: Significant evidence for a heritable contribution to cancer predisposition: a review of cancer familiality by site

Cancer N Case GIF Mean Control GIF Case dGIF Mean Control dGIF SD Control GIF SD Control dGIF Empirical p GIF Empirical p dGIF
Chronic Lymphocytic Leukemia 978 7.90 4.76 5.10 4.14 0.26 0.20 < 0.0001 < 0.0001
Small Intestine 387 7.49 4.67 4.56 4.12 0.53 0.38 < 0.0001 0.137
Lip 1077 7.26 4.83 4.89 4.14 0.25 0.20 < 0.0001 0.0001
Thyroid 1865 6.38 4.49 4.48 4.07 0.13 0.11 < 0.0001 0.0006
Testis 691 5.97 4.37 4.18 4.01 0.26 0.20 < 0.0001 0.1943
Multiple Myeloma 1268 5.90 4.76 4.59 4.14 0.21 0.17 < 0.0001 0.0067
Prostate 18069 5.57 4.76 4.44 4.15 0.03 0.03 < 0.0001 < 0.0001
Melanoma 4463 5.56 4.57 4.53 4.11 0.08 0.07 < 0.0001 < 0.0001
Colon 6285 5.49 4.78 4.26 4.13 0.07 0.06 < 0.0001 0.0233
Lung/Bronchus 5063 5.42 4.75 4.27 4.14 0.08 0.07 < 0.0001 0.046
Rectum 2472 5.38 4.73 4.34 4.13 0.13 0.11 < 0.0001 0.032
Kidney 1791 5.35 4.65 4.36 4.12 0.15 0.13 < 0.0001 0.035
Ovary 1941 5.32 4.68 4.27 4.11 0.14 0.12 < 0.0001 0.1042
Non Hodgkin Lymphoma 3267 5.26 4.65 4.44 4.12 0.10 0.08 < 0.0001 0.0002
Breast 12523 5.10 4.70 4.16 4.12 0.04 0.04 < 0.0001 0.2009
Stomach 1490 5.66 4.86 4.32 4.16 0.19 0.16 0.0001 0.1553
Pancreas 1893 5.45 4.77 4.32 4.13 0.16 0.13 0.0001 0.0757
Bladder 2455 5.29 4.84 4.15 4.14 0.13 0.11 0.0008 0.4479
Hodgkin Lymphoma 752 5.25 4.44 3.88 4.03 0.26 0.20 0.0018 0.7628
Endometrial 3155 5.04 4.72 4.03 4.12 0.11 0.09 0.002 0.8261
Cervix 922 5.35 4.68 4.20 4.12 0.26 0.20 0.007 0.3315
Larynx 427 6.06 4.76 4.41 4.14 0.52 0.38 0.0121 0.2366
Brain 1488 4.83 4.45 4.03 4.03 0.16 0.13 0.0124 0.5067
Anus 396 6.33 4.98 4.81 4.17 0.62 0.43 0.0226 0.079
Genital Female 365 6.01 4.75 4.32 4.12 0.60 0.43 0.0266 0.3117
Salivary 338 5.95 4.68 4.52 4.13 0.61 0.44 0.0286 0.1808
Liver/Hepatic 449 5.50 4.63 4.32 4.10 0.47 0.34 0.0418 0.253
Pharynx 315 5.82 4.64 3.30 4.10 0.65 0.46 0.0447 0.9682
Acute Myelogenous Leukemia 920 5.01 4.62 3.84 4.09 0.25 0.19 0.0651 0.8933
Tongue 347 5.57 4.65 3.49 4.13 0.58 0.42 0.0686 0.9418
Acute Lymphocytic Leukemia 409 4.58 4.14 3.98 3.83 0.38 0.27 0.1284 0.2822
Gallbladder 306 5.49 4.90 4.15 4.15 0.77 0.53 0.2106 0.4799
Esophagus 520 4.83 4.71 3.90 4.15 0.42 0.31 0.3814 0.7854
Chronic Myelogenous Leukemia 343 4.59 4.69 4.16 4.10 0.61 0.44 0.5345 0.4319
Oropharynx 261 4.48 4.68 3.37 4.13 0.77 0.54 0.5686 0.9274
Bone 294 3.66 4.34 3.66 3.97 0.56 0.40 0.9014 0.7829