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Table 3 Correlation of CD4+ and FOXP3+ TILs with hormone receptor and her2/neu status in ductal carcinomas

From: Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+tumor infiltrating lymphocytes in ductal and lobular breast cancers

Compartment/TIL subtype ER status PR status Her2/neu
  - + p-value - + p-value - + p-value
Total          
CD4 + 25.1 ± 29.7 15.6 ± 22.9 < 0.001 12.4 ± 19.3 17.9 ± 25.2 0.008 17.0 ± 24.5 22.4 ± 27.4 0.023
FOXP3 + 11.9 ± 16.1 6.9 ± 11.3 < 0.001 8.6 ± 13.4 6.7 ± 10.9 0.203 7.6 ± 12.6 10.6 ± 13.0 < 0.001
Intratumoral          
CD4 + 17.5 ± 23.4 10.7 ± 18.5 < 0.001 8.2 ± 13.6 12.7 ± 21.6 0.032 11.7 ± 19.7 15.6 ± 21.8 0.036
FOXP3 + 7.0 ± 12.8 3.0 ± 7.0 < 0.001 4.0 ± 9.2 2.7 ± 6.1 0.12 3.7 ± 8.7 4.7 ± 8.1 0.009
  1. Mean ± SD, counts of immunoreactive lymphocytes CD4+ and FOXP3+ Wilcoxon Rank Sum Test; *after adjustment for multiple comparisons, only p < 0.001 was considered statistically significant
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