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Figure 4 | BMC Cancer

Figure 4

From: Differential pattern and prognostic significance of CD4+, FOXP3+ and IL-17+tumor infiltrating lymphocytes in ductal and lobular breast cancers

Figure 4

Overall survival analysis in patients with ductal breast cancer. A: Overall survival in patients with ductal carcinomas and high and low level of CD4+ TILs. Kaplan-Meier survival curves (univariate-analysis) of ductal breast cancers and overall survival in patients with high level of CD4+ versus low level of CD4+ cells infiltrating the tumor. CD4+ infiltrating cells: high level of CD4+ violet curve; low level of CD4+ black curve. Patients with high level of CD4+ cell infiltration show a significant (p = 0.031) worse survival (cut-off established by ROC curves: > 6 CD4+ TILs). B: Overall survival in patients with ductal carcinomas according to total FOXP3/CD4 ratio > or < 1. Kaplan-Meier survival curves (univariate-analysis) of ductal breast cancers and overall survival in patients with ratio of total FOXP3+/CD4+ cells > 1 (blue curve) or < 1 (black curve). Patients with a > 1 ratio had a significantly better survival (p = 0.0005).

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