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Table 4 Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with overall survival (OS)

From: Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

Variable

Univariate analysis

Multivariate analysis

 

HR

CI(95%)

Pvalue

HR

CI(95%)

Pvalue

Sex

      

   Female

1

     

   Male

1.008

0.683-1.488

0.967

   

Age at surgery, years

      

   < 65

1

     

   ≥ 65

1.201

0.813-1.773

0.357

   

Tumor location

      

   Colon

1

  

1

  

   Rectum

1.560

1.044-2.331

0.030

1.794

1.191-2.701

0.005

TNM stage

      

   I-II

1

  

1

  

   III-IV

2.884

1.932-4.306

< 0.001

2.287

1.490-3.510

< 0.001

pT (invasion depth)

      

   T1-T2

1

     

   T3-T4

1.373

0.794-2.376

0.257

   

pN (lymph node metastasis)

      

   N0

1

     

   N1-N2

2.346

1.586-3.469

< 0.001

   

pM (distant metastasis)

      

   M0

1

     

   M1

7.292

4.601-11.558

< 0.001

   

Differentiation grade

      

   Well and Moderate

1

  

1

  

   Poorly

3.206

1.900-5.409

< 0.001

2.853

1.658-4.907

< 0.001

Preoperative CEA level

      

   < 5 ng/ml

1

  

1

  

   ≥ 5 ng/ml

1.904

1.287-2.817

0.001

1.280

0.834-1.964

0.259

Preoperative CA19-9 level

      

   < 60 U/ml

1

  

1

  

   ≥ 60 U/ml

1.911

1.119-3.262

0.018

1.587

0.905-2.782

0.107

Phospho-MEK5 protein

      

   Normal expression

1

  

1

  

   Overexpression

2.107

1.376-3.227

< 0.001

1.518

0.964-2.388

0.071

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BMC Cancer

ISSN: 1471-2407

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