From: Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer
Variable | Univariate analysis | Multivariate analysis | ||||
---|---|---|---|---|---|---|
 | HR | CI(95%) | Pvalue | HR | CI(95%) | Pvalue |
Sex | Â | Â | Â | Â | Â | Â |
   Female | 1 |  |  |  |  |  |
   Male | 1.008 | 0.683-1.488 | 0.967 |  |  |  |
Age at surgery, years | Â | Â | Â | Â | Â | Â |
   < 65 | 1 |  |  |  |  |  |
   ≥ 65 | 1.201 | 0.813-1.773 | 0.357 |  |  |  |
Tumor location | Â | Â | Â | Â | Â | Â |
   Colon | 1 |  |  | 1 |  |  |
   Rectum | 1.560 | 1.044-2.331 | 0.030 | 1.794 | 1.191-2.701 | 0.005 |
TNM stage | Â | Â | Â | Â | Â | Â |
   I-II | 1 |  |  | 1 |  |  |
   III-IV | 2.884 | 1.932-4.306 | < 0.001 | 2.287 | 1.490-3.510 | < 0.001 |
pT (invasion depth) | Â | Â | Â | Â | Â | Â |
   T1-T2 | 1 |  |  |  |  |  |
   T3-T4 | 1.373 | 0.794-2.376 | 0.257 |  |  |  |
pN (lymph node metastasis) | Â | Â | Â | Â | Â | Â |
   N0 | 1 |  |  |  |  |  |
   N1-N2 | 2.346 | 1.586-3.469 | < 0.001 |  |  |  |
pM (distant metastasis) | Â | Â | Â | Â | Â | Â |
   M0 | 1 |  |  |  |  |  |
   M1 | 7.292 | 4.601-11.558 | < 0.001 |  |  |  |
Differentiation grade | Â | Â | Â | Â | Â | Â |
   Well and Moderate | 1 |  |  | 1 |  |  |
   Poorly | 3.206 | 1.900-5.409 | < 0.001 | 2.853 | 1.658-4.907 | < 0.001 |
Preoperative CEA level | Â | Â | Â | Â | Â | Â |
   < 5 ng/ml | 1 |  |  | 1 |  |  |
   ≥ 5 ng/ml | 1.904 | 1.287-2.817 | 0.001 | 1.280 | 0.834-1.964 | 0.259 |
Preoperative CA19-9 level | Â | Â | Â | Â | Â | Â |
   < 60 U/ml | 1 |  |  | 1 |  |  |
   ≥ 60 U/ml | 1.911 | 1.119-3.262 | 0.018 | 1.587 | 0.905-2.782 | 0.107 |
Phospho-MEK5 protein | Â | Â | Â | Â | Â | Â |
   Normal expression | 1 |  |  | 1 |  |  |
   Overexpression | 2.107 | 1.376-3.227 | < 0.001 | 1.518 | 0.964-2.388 | 0.071 |