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Table 4 Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with overall survival (OS)

From: Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

Variable Univariate analysis Multivariate analysis
  HR CI(95%) Pvalue HR CI(95%) Pvalue
Sex       
   Female 1      
   Male 1.008 0.683-1.488 0.967    
Age at surgery, years       
   < 65 1      
   ≥ 65 1.201 0.813-1.773 0.357    
Tumor location       
   Colon 1    1   
   Rectum 1.560 1.044-2.331 0.030 1.794 1.191-2.701 0.005
TNM stage       
   I-II 1    1   
   III-IV 2.884 1.932-4.306 < 0.001 2.287 1.490-3.510 < 0.001
pT (invasion depth)       
   T1-T2 1      
   T3-T4 1.373 0.794-2.376 0.257    
pN (lymph node metastasis)       
   N0 1      
   N1-N2 2.346 1.586-3.469 < 0.001    
pM (distant metastasis)       
   M0 1      
   M1 7.292 4.601-11.558 < 0.001    
Differentiation grade       
   Well and Moderate 1    1   
   Poorly 3.206 1.900-5.409 < 0.001 2.853 1.658-4.907 < 0.001
Preoperative CEA level       
   < 5 ng/ml 1    1   
   ≥ 5 ng/ml 1.904 1.287-2.817 0.001 1.280 0.834-1.964 0.259
Preoperative CA19-9 level       
   < 60 U/ml 1    1   
   ≥ 60 U/ml 1.911 1.119-3.262 0.018 1.587 0.905-2.782 0.107
Phospho-MEK5 protein       
   Normal expression 1    1   
   Overexpression 2.107 1.376-3.227 < 0.001 1.518 0.964-2.388 0.071