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Table 3 Cox proportional hazards model univariate and multivariate analyses of individual parameters for correlations with disease-free survival (DFS)

From: Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer

Variable Univariate analysis Multivariate analysis
  HR CI(95%) Pvalue HR CI(95%) Pvalue
Sex       
   Female 1      
   Male 0.966 0.662-1.409 0.856    
Age at surgery, years       
   < 65 1      
   ≥ 65 1.228 0.841-1.794 0.287    
Tumor location       
   Colon 1    1   
   Rectum 1.602 1.083-2.368 0.018 1.874 1.255-2.801 0.001
TNM stage       
   I-II 1    1   
   III-IV 2.851 1.933-4.204 < 0.001 2.383 1.572-3.614 < 0.001
pT (invasion depth)       
   T1-T2 1      
   T3-T4 1.398 0.822-2.379 0.216    
pN (lymph node metastasis)       
   N0 1      
   N1-N2 2.351 1.607-3.439 < 0.001    
pM (distant metastasis)       
   M0 1      
   M1 7.250 4.619-11.38 < 0.001    
Differentiation grade       
   Well and Moderate 1    1   
   Poorly 3.082 1.830-5.188 < 0.001 2.988 1.746-5.114 < 0.001
Preoperative CEA level       
   < 5 ng/ml 1    1   
   ≥ 5 ng/ml 1.748 1.196-2.556 0.004 1.192 0.789-1.801 0.405
Preoperative CA19-9 level       
   < 60 U/ml 1    1   
   ≥ 60 U/ml 1.926 1.146-3.236 0.013 1.779 1.035-3.056 0.037
Phospho-MEK5 protein       
   Normal expression 1    1   
   Overexpression 1.898 1.264-2.850 0.002 1.388 0.900-2.141 0.139