Figure 1
From: Expression of the phosphorylated MEK5 protein is associated with TNM staging of colorectal cancer
Immunohistochemical analysis of the expression of pMEK5 protein. pMEK5 expression was localized within the cytoplasm. A1 and A2, Elevated pMEK5 expression in the tumor cells of CRC tissue (T) compared with those of adjacent normal mucosa (N); B1 and B2, only weak staining of pMEK5 was detected in normal colorectal epithelial tissue; C1 and C2, moderately positive expression of pMEK5 in CRC without distant metastasis; D1 and D2, strongly positive expression of pMEK5 in CRC with distant metastasis (Left panels, ×100, right panels, ×400).