Pt. | Protocol type | Initial surgery | CT (No. of cycles) | Response to CT | Delayed surgery | RT (dose) | Outcome (years after diagnosis) | Long-term sequelae |
---|---|---|---|---|---|---|---|---|
1 | RMS | Macroscopic residuals | VAdIA (9) | PR | No | No | DOD (0.7) | - |
2 | RMS | Biopsy | VAdIA (12) | CR | No | Yes (53 Gy) | NED (11.5) | GH deficit, hypogonadism, hypothyroidism, chronic sinusitis, hypovision and cataract, hearing loss, dental abnormalities, facial bones hypoplasia |
3 | RMS | Biopsy | VAdIA + Carbo/E (5) | PR | Microscopic residuals | Yes (50 Gy) | NED (13) | Palate deformity |
4 | RMS | Biopsy | VAdIA (12) | MR | Complete resection | Yes (60 Gy) | NED (14) | Hypothyroidism, xerostomia, oligospermia |
5 | RMS | Microscopic residuals | VAdIA (9) | NE | No | Yes* (42 Gy) | NED (9.2) | Chronic headache, hypothyroidism, attention-deficit/hyperactivity disorder |
6 | NBL | Macroscopic residuals | VAdC + CDDP/E (6) | SD | Microscopic residuals | Yes (48 Gy) | NED (11.1) | loss of sense of smell, facial bone hypoplasia, recurrent keratoconjunctivitis, maculopathy |
7 | NBL | Biopsy | VAdCA + CDDP/E+ i.t. MTX (15) | PR | No | Yes (60 Gy) | NED (23) | Amaurosis, hypothyroidism, GH deficiency, xerostomia, facial bones hypoplasia |
8 | NBL | Lymph node biopsy | VAdC/CDDP (7) | CR | No | Yes (47 Gy) | NED (20.2) | Peripheral neuropathy |
9 | RMS | Macroscopic residuals | VAdC (12) | NE | No | Yes (60 Gy) | NED (17.1) | Chronic sinusitis |