Peritumoral vascular invasion and NHERF1 expression define an immunophenotype of grade 2 invasive breast cancer associated with poor prognosis

Table 2 Association between tumor markers expression and clinicopathological features

Parameter	Cytoplasmic NHERF1	Membranous NHERF1	HIF-1α	VEGFR1	TWIST1
	Positive	Positive	Positive	Positive	Positive
Tumor grade
1	6 (21)	7 (25)	13 (48)	12 (44)	15 (58)
2	17 (24)	14 (19)	33 (49)	34 (46)	35 (57)
3	23 (43)	3 (6)	12 (20)	36 (57)	23 (43)
p value¹	0.035	0.037	0.001	NS	NS
PR status
Negative	27 (43)	4 (6)	29 (44)	43 (63)	29 (45)
Positive	19 (22)	16 (18)	18 (24)	37 (40)	42 (56)
p value²	0.008	0.031	0.013	0.006	NS
MIB1
Negative	14 (22)	13 (21)	20 (28)	30 (44)	38 (61)
Positive	34 (40)	7 (8)	37 (46)	50 (54)	33 (43)
p value²	0.033	0.029	0.020	NS	0.040
HER2 status
Negative	34 (29)	15 (12)	46 (37)	67 (53)	55 (49)
Positive	11 (55)	2 (11)	8 (40)	11 (55)	14 (70)
p value²	0.036	NS	NS	NS	NS
NPI
Good	5 (13)	10 (26)	10 (24)	18 (45)	21 (58)
Moderate	24 (32)	8 (11)	28 (37)	40 (50)	33 (49)
Poor	15 (38)	2 (5)	20 (53)	24 (55)	19 (49)
p value¹	0.029	0.016	0.029	NS	NS

Data presented as number of tumors and (%)
Abbreviations: Tumor grade = histological differentiation grade; PR = progesterone receptor; HER2 = human epidermal growth factor receptor 2; NPI = Nottingham Prognostic Index.
¹ p values were calculated with the use of the χ ² test;
² p values were calculated with the use of the Fisher's exact test

ISSN: 1471-2407