Table 1 KRAS genotype frequencies in the study population
Study population | Genotype | Frequency N % | OR (95% CI) | p value |
|---|---|---|---|---|
Controls | wild (TT) | 221/269 (82.2) | 1.0 | Â |
| Â | variable (TG/GG) | 48/269 (17.8) | Â | Â |
Sporadic cases | wild (TT) | 434/524 (82.8) | 0.96 (0.65-1.40) | 0.814 |
| Â | variable (TG/GG) | 90/524 (17.2) | Â | Â |
Familial cases | wild (TT) | 135/165 (81.8) | 1.02 (0.62-1.69) | 0.929 |
| Â | variable (TG/GG) | 30/165 (18.2) | Â | Â |
BRCA carriers | wild (TT) | 26/29 (89.7) | 0.53 (0.15-1.83) | 0.316 |
| Â | variable (TG/GG) | 3/29 (10.3) | Â | Â |
BRCA1 carriers | wild (TT) | 18/20 (90.0) | 0.51 (0.12-2.28) | 0.379 |
| Â | variable (TG/GG) | 2/20 (10.0) | Â | Â |
BRCA2 carriers | wild (TT) | 8/9 (88.9) | 0.58 (0.07-4.71) | 0.606 |
| Â | variable (TG/GG) | 1/9 (11.1) | Â | Â |
Non-BRCA carriers | wild (TT) | 109/136 (80.1) | 1.14 (0.68-1.93) | 0.623 |
| Â | variable (TG/GG) | 27/136 (19.9) | Â | Â |