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Table 2 Mean Natural Log (ng/g) Values of Baseline (BL), 2 Month (2 Mo) and Wean (W) Samples vs.

From: Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy

Age (yrs) < 26      > = 26     
Biomarker BL 2Mo W P (overall) P (pairs)1 BL 2Mo W P (overall) P (pairs)1
KLK2 0.91 0.96 0.89 NS2 NS2 1.03 1.09 0.93 NS NS
KLK3 2.36 1.75 0.80 0.0011 *, ††† 2.42 1.56 1.89 NS *
KLK4 -0.75 -0.68 0.13 0.0088 †, ^ -0.88 -0.65 -0.09 NS ††
KLK5 8.51 7.83 9.17 5.49E-11 **, ^^ 8.43 7.21 8.92 1.22E-10 ***,^^^
KLK6 9.88 10.1 10.9 4.61E-11 ***, †††,^^^ 9.79 9.89 10.6 1.56E-6 †††,^^^
KLK7 5.52 4.45 6.18 0.0039 **, ^^ 5.03 4.79 5.25 NS NS
KLK8 8.10 8.32 9.54 5.16E-10 *,†††.^^^ 7.84 8.20 9.04 1.49E-10 ***,†††,^^^
KLK10 5.18 5.97 7.18 0.0011 **,††,^^ 4.77 5.59 7.15 2.3-4 *,††,^^
KLK11 6.44 4.73 6.57 5.35E-5 ***,^ 6.36 4.95 5.78 0.0049 **
KLK13 2.56 1.87 1.25 NS †,^ 2.11 2.01 1.14 NS NS
KLK14 1.10 0.89 1.46 0.046 ††,^^ 1.18 0.83 1.21 NS ^^
N(all KLKs) 37 36 20    32 33 21   
YKL40 12.1 10.6 12.2 2.38E-6 ***,^^ 12.3 10.1 12.0 3.88E-11 ***,^^^
NGAL 8.31 7.23 8.37 4.5E-4 ***,^^ 8.91 7.16 8.36 6.96E-12 ***,^^^
bFGF -1.46 -3.15 -1.91 2.58E-8 ***,^^^ -1.07 -2.89 -1.85 NS ***,††,^^
TGFβ1 3.88 3.52 4.23 5.49E-5 **,^^ 3.88 3.36 4.40 2.34E-5 **,†,^^^
TGFβ2 5.55 5.25 7.06 7.27E-7 †††,^^^ 5.47 5.03 7.09 2.74E-12 *,†††,^^^
N(non-KLKs) 37 36 21    34 34 26   
  1. Age at First Full Term Pregnancy
  2. 1: P (pairs): paired comparisons. *: BL vs. 2 Mo; †: BL vs. W; ^: 2 Mo. vs. W. One mark (*, †, or ^): p < 0.05; two marks: p < 0.01; three marks: p < 0.001. P values adjusted for multiple comparisons using Holm's step-down procedure
  3. 2: NS: not significant. If NS is listed under P (pairs), it indicates that there were no significant associations for any of the three paired comparisons
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BMC Cancer

ISSN: 1471-2407

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