Skip to main content

Table 5 Details of genes with differential copy number and expression between K-Ras mutant and wild-type tumours

From: Integrated mutation, copy number and expression profiling in resectable non-small cell lung cancer

Symbol

Gene name

Cytoband

Difference in expression

(log2 mutant - wild type)

P value

RGS2

Regulator of G-protein signaling 2, 24kDa

1q31

1.99

5.9 E-3

NCAM1

Neural cell adhesion molecule 1

11 ( multiple clusters)

-1.63

1.5 E-3

CD55

CD55 molecule, decay accelerating factor for complement (Cromer blood group)

1q32

1.49

6.9 E-4

PTGS2/COX-2

Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)/Cyclooxygenase-2

1q25.2-q25.3

1.32

3.1 E-3

ECM1

Extracellular matrix protein 1

1q21

1.21

5.9 E-3

EXTL2

Exostoses (multiple)-like 2

1p21

-1.08

4.2 E-3

HIST2H2BE

Histone cluster 2, H2be

1q21-q23

1.07

2.7 E-3

H2AA

Histone 2

1q21

0.95

1.2 E-3

CHEK1

CHK1 checkpoint homolog (S. pombe)

11q24-q24

-0.94

6.1 E-3

GPX7

Glutathione peroxidase 7

1p32

-0.88

5.6 E-3

RWDD2A

RWD domain containing 2A

6q14.2

-0.80

8.7 E-4

HSF2

Heat shock transcription factor 2

6q22.31

-0.78

1.6 E-3

BLR1

Burkitt lymphomas receptor 1, GTP binding protein (chemokine (CXC motif) receptor 5)

11q23.3

-0.69

7.4 E-3

MIZF

MBD2-interacting zinc finger

11q23.3

-0.69

5.9 E-3

KPNA5

Karyopherin alpha 5 (importin alpha 6)

6q22.2

-0.66

8.7 E-3

LMO4

LIM domain only 4

1p22.3

-0.66

3.2 E-3

MUTYH

MutY homolog (E. coli)

1p34.3-p32.1

-0.65

4.9 E-4

REV3L

REV3-like, catalytic subunit of DNA polymerase zeta (yeast)

6q21

-0.65

8.8 E-3

EPHB2

Ephrin B2

1p36.1-p35

-0.64

6.7 E-3

DGKZ

Diacylglycerol kinase, zeta 104kDa

11p11.2

-0.64

9.2 E-3

TSPYL4

TSPY-like 4

6q22.1

-0.63

1.6 E-3

DBT

Dihydrolipoamide branched chain transacylase E2

1p31

-0.58

5.8 E-3

FOXO3

Forkhead box O3

6q21

-0.53

5.7 E-3

PPP2R1B

Protein phosphatase 2, regulatory subunit A, beta isoform

11q23.2

-0.51

2.7 E-3

PTPRK

Protein tyrosine phosphatase, receptor type, kappa

6q22.2-q22.3

-0.08

4.3 E-4