Diet folate, DNA methylation and genetic polymorphisms of MTHFRC677T in association with the prognosis of esophageal squamous cell carcinoma

Table 4 Diet folate intake and MTHFR C677T polymorphism in the prognosis of ESCC

MTHFRC677T	Folate intake^†	Total patients	Death, N(%)	aHR(95% CI)*	P
Overall	Low	39	22(56.41)	1
	Moderate	38	19(50.00)	0.72(0.36-1.46)	0.366
	High	38	14(36.84)	0.39(0.20-0.78)	0.007
	P for trend				0.007
CC	Low	12	7(58.33)	1
	Moderate	12	6(50.00)	0.33(0.07-1.50)	0.152
	High	11	3(27.27)	0.14(0.03-0.76)	0.023
	P for trend				0.025
CT	Low	19	13(68.42)	1
	Moderate	13	5(38.46)	0.62(0.18-2.09)	0.441
	High	19	8(42.11)	0.42(0.17-1.01)	0.054
	P for trend				0.053
TT	Low	8	2(25.00)	1
	Moderate	13	8(61.54)	1.46(0.22-9.68)	0.696
	High	8	3(37.50)	0.88(0.09-8.74)	0.914
	P for trend				0.921

† The cut point of folate intake is tertile (μg/d). Low: <30.0; moderate: 30.0-95.4; high: ≥95.5
*: aHR(95% CI), adjusted hazard ratio (95% confidence interval); adjusted for age, sex, T stage and N stage

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