Diet folate, DNA methylation and genetic polymorphisms of MTHFRC677T in association with the prognosis of esophageal squamous cell carcinoma

Table 3 Association between aberrant DNA methylation and the prognosis of ESCC

Characteristics	Total patients	Death, N(%)	HR(95% CI)^†	P
Cancer tissue
P16
Unmethylated	14	8(57.14)	1
Methylated	106	50(47.17)	0.67(0.32-1.41)	0.288
MGMT
Unmethylated	88	43(48.86)	1
Methylated	32	15(46.88)	1.00(0.55-1.79)	0.989
hMLH1
Unmethylated	116	56(48.28)	1
Methylated	4	2(50.00)	1.16(0.28-4.76)	0.836
Any gene
Unmethylated	11	5(45.45)	1
Methylated	109	53(48.62)	1.07(0.43-2.69)	0.880
Remote normal appearing tissue
P16
Unmethylated	74	36(48.65)	1
Methylated	46	22(47.83)	1.02(0.60-1.74)	0.937
MGMT
Unmethylated	107	51(47.66)	1
Methylated	13	7(53.85)	1.35(0.61-2.97)	0.461
hMLH1
Unmethylated	120	58(48.33)	-	-
Methylated	0	-	-	-
Any gene
Unmethylated	67	32(47.76)	1
Methylated	53	26(49.06)	1.13(0.67-1.89)	0.655
MTHFR C677T
CC	35	16(45.71)	1
CT	54	28(51.85)	1.15(0.62-2.13)	0.653
TT	31	14(45.16)	0.98(0.48-2.02)	0.964
CT+TT	85	42(49.41)	1.09(0.61-1.94)	0.770

ISSN: 1471-2407