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Figure 5 | BMC Cancer

Figure 5

From: Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts

Figure 5

Quantitative real-time PCR analysis of the mRNA levels of TβRI, TβRII, and TβRIII in CAFs and in CAFs in response to TGF-β1 (10 ng/ml) stimulation. (A) The expression levels of TβRI were not significantly different in CAFs and NFs (P = 0.362); TGF-β1 treatment didn't change the TβRI levels in CAFs or in NFs. (B) TβRII mRNA expression was reduced in CAFs compared with NFs (*P = 0.004); The levels of expression of TβRII in oral CAFs or NFs were significantly decreased after treatment with 10 ng/ml TGF-β1 (*P = 0.0025). (C) TβRIII mRNA expression in CAFs was also significantly different from that of the control group (**P = 0.001). The levels of expression of TβRIII in oral CAFs or NFs were also significantly decreased after treatment with 10 ng/ml TGF-β1 (**P = 0.0035). (D, E) The maximal downregulation in oral CAFs with TGF-β1 was observed at 6-12 h. (F, G) The maximal downregulation in NFs with TGF-β1 was observed at 6 h.

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