TY - JOUR AU - Hu, Yi-Yang AU - Zheng, Min-Hua AU - Cheng, Gang AU - Li, Liang AU - Liang, Liang AU - Gao, Fang AU - Wei, Ya-Ning AU - Fu, Luo-An AU - Han, Hua PY - 2011 DA - 2011/02/22 TI - Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells JO - BMC Cancer SP - 82 VL - 11 IS - 1 AB - Cancer stem cells (CSCs) play an important role in the development and recurrence of malignant tumors including glioma. Notch signaling, an evolutionarily conserved pathway mediating direct cell-cell interaction, has been shown to regulate neural stem cells (NSCs) and glioma stem cells (GSCs) in normal neurogenesis and pathological carcinogenesis, respectively. However, how Notch signaling regulates the proliferation and differentiation of GSCs has not been well elucidated. SN - 1471-2407 UR - https://doi.org/10.1186/1471-2407-11-82 DO - 10.1186/1471-2407-11-82 ID - Hu2011 ER -