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Table 2 Profile of Microsatellite instability (MSI), mismatch repair (MMR) deficiency and promoter methylation in 6 colon cancer cell lines.

From: Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

  

MMR

deficiency*

Methylation**

Cell lines

MSI

MLH1

MSH2

MLH1

p16

PXR

LS180

+

+

-

M

?

U

LoVo

+

-

+

U

M

U

Caco-2

-

-

-

?

?

M

HT29

-

-

-

U

M

M

HCT116

+

+

-

U

M

M

SW48

+

+

-

M

M

M

  1. Summary of previous studies [27, 28] and the present study (PXR methylation).
  2. *Mismatch repair deficiency was associated with mutations or defects in mRNA transcripts.
  3. **Methylation status was defined as unmethylated (U) or methylated (M).
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BMC Cancer

ISSN: 1471-2407

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