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Table 2 Profile of Microsatellite instability (MSI), mismatch repair (MMR) deficiency and promoter methylation in 6 colon cancer cell lines.

From: Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

   MMR
deficiency*
Methylation**
Cell lines MSI MLH1 MSH2 MLH1 p16 PXR
LS180 + + - M ? U
LoVo + - + U M U
Caco-2 - - - ? ? M
HT29 - - - U M M
HCT116 + + - U M M
SW48 + + - M M M
  1. Summary of previous studies [27, 28] and the present study (PXR methylation).
  2. *Mismatch repair deficiency was associated with mutations or defects in mRNA transcripts.
  3. **Methylation status was defined as unmethylated (U) or methylated (M).