Table 3 Genes Known To Be Up or Down-Regulated In Cervical Cancers Found Also In Our Study
From: Identification and validation of genes involved in cervical tumourigenesis
UP-REGULATED | |||
|---|---|---|---|
S NO: | GENE SYMBOL | FUNCTION | REFERENCES |
1 | CCNB1 | Cell cycle | Overexpressed in cervical cancers [62] |
2 | CDC20 | Cell cycle | HR-HPV E2 interaction [63] |
3 | CDC25B | Cell cycle | FOXM1 increases Cyclin B1, CDC25B, Cyclin D1 in cervical cancers [64] |
4 | CDH3 | Cell adhesion | P-Cadherin predominant cadherin in high grade cervical dysplasia [65] |
5 | CDKN2A | Cell cycle | Overexpressed in high grade dysplasia and invasive cancers [66] |
6 | CKS2 | Cell cycle | Overexpressed in cervical cancer [67] |
7 | DTX3L | Ubiquitin pathway | Overexpressed in cervical cancer [68] |
8 | INDO/IDO1 | Immuno-suppression | Role in inducing immunosuppression in the tumour milleu [69] |
9 | ISG15/G1P2 | Ubiquitin like protein | Over-expressed in invasive cancer [70] |
10 | ISG20 | Exonuclease with higher affinity for RNA | Up-regulated by HPV E6 [71] |
11 | KRT17 | Intermediate filament; marker for epithelial "stem cells" | Overexpressed in cervical cancer [72] |
12 | LAMB3 | Basement membrane protein | HR-HPV-E6 inhibits miR-218 which regulates LAMB3 [73] |
13 | MCM4 | Cell cycle | Widely expressed in cervical cancers [74] |
14 | MCM6 | Cell cycle | Over-expressed in cancer [75] |
15 | MMP1 | Breakdown of extracellular matrix | Overexpressed in cervical cancers [76] |
16 | MMP3 | Breakdown of extracellular matrix | Metastatic lymphnodes in cervical cancer harbour MMP3 positive tumour cells [77]; Increased in stroma in cancers [78] |
17 | SLC2A1 | Glucose transporter | Expressed in CIN and invasive cervical cancers [79] |
18 | STAT1 | Transcription activator | Overexpressed in cervical cancers [80] |
19 | TK1 | Thymidine kinase | Up-regulated in invasive cancers [81] |
20 | TOP2A | Topoisomerase | Overexpressed in cervical cancers [82] |
21 | UBE2C | Ubiquitin pathway | Overexpressed in cervical cancer [76] |
| Â | CIN3 | Â | Â |
1 | PCNA | Cell cycle | Major up-regulation of PCNA upon progression to CIN3 [83] |
DOWN-REGULATED | |||
1 | FBLN1 | Cell adhesion; tumour suppressor | E6 binds to Fibulin1 and modulates its activity [84] |
2 | CD36 | Cell adhesion | CD36 down-regulated in high grade dysplasias and cancer [85] |
3 | CXCL14 | Immunoregulatory cytokine | Down-regulated in cervical and head and neck cancers [86] |
4 | GJA1 | Gap junction | Down-regulated in CIN3 and invasive cancers [87] |
5 | KRT10 | Intermediate filament | Down-regulated in invasive cancer [72] |