From: Identification and validation of genes involved in cervical tumourigenesis
S. No: | GENE SYMBOL | FUNCTION | CANCERS WHEREIN UP-REGULATION REPORTED |
---|---|---|---|
1 | AGRN | Basement membrane component | |
2 | CCL18 | Attracts lymphocytes towards dendritic cell | Gastric cancer [29] |
3 | CKS1B | Cell cycle | Breast cancer [30] etc. |
4 | COL7A1 | Epithelial basement membrane organization | Oesophageal cancer [31] |
5 | DNYLL1/DLC1 | Inhibits neuronal nitric oxide synthase | Breast cancer [32] |
6 | FERMT1 | Cell adhesion; TGF-β signalling | Lung and colon cancer [33] |
7 | FST | Activin antagonist; inhibits synthesis and secretion of FSH | Wilm's tumour, Basal cell carcinoma [34] |
8 | IGF2BP2 | Regulate translation of target mRNA | |
9 | IL8 | Inflammatory cytokine | Several cancers; HR-HPV+VIN [37] |
10 | KLK9 | Serine protease | |
11 | MELK | Leucine zipper kinase | |
12 | PLOD2 | Lysyl hydroxylase | Glioblastoma [42] |
13 | RASSF6 | Tumour suppressor | Low levels detected in HeLa cell line [43] |
14 | SLC16A1 | Monocarboxylate transporter | Neuroblastoma [44] |
15 | SMC4 | Chromosome condensation; DNA repair | Breast cancer [45] |
16 | APOBEC3B | RNA editing enzyme | None to date |
17 | ASB16 | Ubiquitin pathway | None to date |
18 | NUP210 | Nuclear pore complex | None to date |
19 | THOC6 | Splicesome associated protein | None to date |
20 | TMEM123 | Induces Pro-oncosis type cell death | None to date |
 | CIN3 |  |  |
1 | CCNB2 | Cell cycle | |
2 | EBP | ER Protein | ALK+ Anaplastic large cell lymphoma [48] |
3 | NUSAP1 | Microtubule associated protein | Melanoma [49] |
4 | CALML5 | Calcium binding protein | Psoriasis [50] |
5 | FLJ44635 | TPT1-like protein | None to date |
 |  |  | CANCERS WHEREIN DOWN-REGULATION REPORTED |
1 | C20ORF114 | Innate immunity | Nasopharyngeal cancer [51] |
2 | CRNN | Tumour suppressor | Tongue cancer [52] |
3 | CSTB | Thiol proteinase inhibitor; anti-metastatic | Laryngeal cancer [53] |
4 | DBI | Intracellular carrier for Acyl-COA esters | Overexpressed in Brain tumours [54] |
5 | FCGBP | Maintenance of mucosal surface | Prostate [55] |
6 | HOPX | Tumour suppressor | |
7 | SLURP1 | Anti-tumour; anti-angiogenic | Hypopharyngeal cancer; Can induce apoptosis in Kaposi's sarcoma [58] |
8 | SPINK5 | Serine protease inhibitor | Tongue cancer [59] |
9 | TFF3 | Protect mucosa | Down-regulated in highly invasive colon cancers [60] and in thyroid cancers [61] |
10 | CAPNS2 | Thiol protease | None to date |
11 | DAPL1 | Epithelial differentiation | None to date |
12 | GLB1L3 | Galactosidase beta1 like | None to date |
13 | HEBP2 | Heme binding protein | None to date |
14 | KRTDAP | Keratinocyte differentiation | None to date |