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Table 2 Genes Identified as Up or Down-Regulated In Cervical Cancers For The First Time

From: Identification and validation of genes involved in cervical tumourigenesis

S. No:

GENE SYMBOL

FUNCTION

CANCERS WHEREIN UP-REGULATION REPORTED

1

AGRN

Basement membrane component

Hepatocellular carcinoma (HCC)[27], Synovial sarcoma [28]

2

CCL18

Attracts lymphocytes towards dendritic cell

Gastric cancer [29]

3

CKS1B

Cell cycle

Breast cancer [30] etc.

4

COL7A1

Epithelial basement membrane organization

Oesophageal cancer [31]

5

DNYLL1/DLC1

Inhibits neuronal nitric oxide synthase

Breast cancer [32]

6

FERMT1

Cell adhesion; TGF-β signalling

Lung and colon cancer [33]

7

FST

Activin antagonist; inhibits synthesis and secretion of FSH

Wilm's tumour, Basal cell carcinoma [34]

8

IGF2BP2

Regulate translation of target mRNA

Testicular cancer [35], HCC [36]

9

IL8

Inflammatory cytokine

Several cancers; HR-HPV+VIN [37]

10

KLK9

Serine protease

Bladder cancer [38], breast cancer [39]

11

MELK

Leucine zipper kinase

Colo-rectal cancer, lung cancer, [40] brain cancer [41]

12

PLOD2

Lysyl hydroxylase

Glioblastoma [42]

13

RASSF6

Tumour suppressor

Low levels detected in HeLa cell line [43]

14

SLC16A1

Monocarboxylate transporter

Neuroblastoma [44]

15

SMC4

Chromosome condensation; DNA repair

Breast cancer [45]

16

APOBEC3B

RNA editing enzyme

None to date

17

ASB16

Ubiquitin pathway

None to date

18

NUP210

Nuclear pore complex

None to date

19

THOC6

Splicesome associated protein

None to date

20

TMEM123

Induces Pro-oncosis type cell death

None to date

 

CIN3

  

1

CCNB2

Cell cycle

Lung [46], pituitary tumours [47]

2

EBP

ER Protein

ALK+ Anaplastic large cell lymphoma [48]

3

NUSAP1

Microtubule associated protein

Melanoma [49]

4

CALML5

Calcium binding protein

Psoriasis [50]

5

FLJ44635

TPT1-like protein

None to date

   

CANCERS WHEREIN DOWN-REGULATION REPORTED

1

C20ORF114

Innate immunity

Nasopharyngeal cancer [51]

2

CRNN

Tumour suppressor

Tongue cancer [52]

3

CSTB

Thiol proteinase inhibitor; anti-metastatic

Laryngeal cancer [53]

4

DBI

Intracellular carrier for Acyl-COA esters

Overexpressed in Brain tumours [54]

5

FCGBP

Maintenance of mucosal surface

Prostate [55]

6

HOPX

Tumour suppressor

Choriocarcinoma [56] and lung cancer [57]

7

SLURP1

Anti-tumour; anti-angiogenic

Hypopharyngeal cancer; Can induce apoptosis in Kaposi's sarcoma [58]

8

SPINK5

Serine protease inhibitor

Tongue cancer [59]

9

TFF3

Protect mucosa

Down-regulated in highly invasive colon cancers [60] and in thyroid cancers [61]

10

CAPNS2

Thiol protease

None to date

11

DAPL1

Epithelial differentiation

None to date

12

GLB1L3

Galactosidase beta1 like

None to date

13

HEBP2

Heme binding protein

None to date

14

KRTDAP

Keratinocyte differentiation

None to date