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Figure 6 | BMC Cancer

Figure 6

From: c-MYC expression sensitizes medulloblastoma cells to radio- and chemotherapy and has no impact on response in medulloblastoma patients

Figure 6

c-MYC expression modulates caspase-9 activation after IR, cispatin, and etoposide treatment of DAOY MB cells. IR (A) triggers caspase-9 cleavage exclusively in c-MYC over-expressing DAOY cells. Caspase-9 cleavage is more pronounced in DAOY M2 cells following treatment with cisplatin (B), or etoposide (C). Cells were irradiated with 5 Gy, treated with cisplatin (0.15 μg/ml) or with etoposide (0.19 μg/ml). Lysates were analyzed at the indicated time points by Western blotting for caspase 8 and 9, and β-actin. Representative blots (two independent experiments) are shown.

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