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Table 2 Effects of ERK targeted docking domain inhibitors on cell proliferation.

From: Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

  76 76.2 76.3 76.4
  HeLa TERT HeLa TERT HeLa TERT HeLa TERT
25 μM 20.1 ± 5.2# 21.7 ± 3.6# 73.7 ± 12.6 81.0 ± 8.1 58.2 ± 7.4# 112.9 ± 19.1 53.7 ± 6.0# 120.0 ± 26.5
50 μM 20.4 ± 4.1# 23.5 ± 12.0* 31.2 ± 12.9# 16.2 ± 4.0# 40.1 ± 8.0# 127.8 ± 12.8 36.3 ± 7.4# 48.1 ± 11.7#
100 μM 20.5 ± 5.9# 29.3 ± 12.1* 17.3 ± 7.1# 19.9 ± 12.5# 17.1 ± 6.1# 53.6 ± 6.8# 21.0 ± 6.3# 45.4 ± 12.6#
  1. HeLa or non-transformed retinal pigment epithelial cells that stably express human telomerase reverse transcriptase (TERT) were seeded at 250 cells/mL and then treated for 7 days with 25-100 uM of the indicated test compound. The proliferation in treated cells is shown as a percentage of control cells (DMSO only set at 100%) following analysis using the WST-1 assay. Data represent mean ± SEM from 3 experiments. * and # indicates statistical significance compared to untreated controls, p ≤ 0.05 and p ≤ 0.01, respectively