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Table 2 Effects of ERK targeted docking domain inhibitors on cell proliferation.

From: Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

 

76

76.2

76.3

76.4

 

HeLa

TERT

HeLa

TERT

HeLa

TERT

HeLa

TERT

25 μM

20.1 ± 5.2#

21.7 ± 3.6#

73.7 ± 12.6

81.0 ± 8.1

58.2 ± 7.4#

112.9 ± 19.1

53.7 ± 6.0#

120.0 ± 26.5

50 μM

20.4 ± 4.1#

23.5 ± 12.0*

31.2 ± 12.9#

16.2 ± 4.0#

40.1 ± 8.0#

127.8 ± 12.8

36.3 ± 7.4#

48.1 ± 11.7#

100 μM

20.5 ± 5.9#

29.3 ± 12.1*

17.3 ± 7.1#

19.9 ± 12.5#

17.1 ± 6.1#

53.6 ± 6.8#

21.0 ± 6.3#

45.4 ± 12.6#

  1. HeLa or non-transformed retinal pigment epithelial cells that stably express human telomerase reverse transcriptase (TERT) were seeded at 250 cells/mL and then treated for 7 days with 25-100 uM of the indicated test compound. The proliferation in treated cells is shown as a percentage of control cells (DMSO only set at 100%) following analysis using the WST-1 assay. Data represent mean ± SEM from 3 experiments. * and # indicates statistical significance compared to untreated controls, p ≤ 0.05 and p ≤ 0.01, respectively
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BMC Cancer

ISSN: 1471-2407

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