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Table 1 Effects of ERK targeted docking domain inhibitors on proliferation of cancer cell lines.

From: Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

Compound HeLa SUM159 HCT-116 SKMEL-28 Panc-1
76 ++ ++ ND ++ ++
76.1 - ++ - - ND
76.2 ++ ++ ++ ++ ND
76.3 ++ ++ ++ ++ ND
76.4 ++ ++ ++ + -
76.5 - - - - ND
76.6 - - - - ND
76.7 - - - - ND
76.8 - - - - ND
76.9 + - ++ + ND
76.10 - - - - ND
17 + ND ND - ND
17.1 - - - - ND
17.2 + ++ ++ + ND
17.3 - - - - ND
17.4 - - - - ND
17.5 - - - - ND
  1. Transformed cell lines from cervical (HeLa), breast (SUM159), colon (HCT-116), skin (SKMEL-28), or pancreatic (Panc-1) tissue were treated for 7 days with 100 μM of the indicated test compound. The proliferation in treated cells is shown relative to control (DMSO only) following analysis using the colony formation assay. (-) ≤ 25%, (+) 25-75%, and (++) ≥75% inhibition; ND, No data