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Table 1 Effects of ERK targeted docking domain inhibitors on proliferation of cancer cell lines.

From: Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

Compound

HeLa

SUM159

HCT-116

SKMEL-28

Panc-1

76

++

++

ND

++

++

76.1

-

++

-

-

ND

76.2

++

++

++

++

ND

76.3

++

++

++

++

ND

76.4

++

++

++

+

-

76.5

-

-

-

-

ND

76.6

-

-

-

-

ND

76.7

-

-

-

-

ND

76.8

-

-

-

-

ND

76.9

+

-

++

+

ND

76.10

-

-

-

-

ND

17

+

ND

ND

-

ND

17.1

-

-

-

-

ND

17.2

+

++

++

+

ND

17.3

-

-

-

-

ND

17.4

-

-

-

-

ND

17.5

-

-

-

-

ND

  1. Transformed cell lines from cervical (HeLa), breast (SUM159), colon (HCT-116), skin (SKMEL-28), or pancreatic (Panc-1) tissue were treated for 7 days with 100 μM of the indicated test compound. The proliferation in treated cells is shown relative to control (DMSO only) following analysis using the colony formation assay. (-) ≤ 25%, (+) 25-75%, and (++) ≥75% inhibition; ND, No data
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BMC Cancer

ISSN: 1471-2407

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