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Figure 2 | BMC Cancer

Figure 2

From: Characterization of ERK Docking Domain Inhibitors that Induce Apoptosis by Targeting Rsk-1 and Caspase-9

Figure 2

Effects of ERK targeted docking domain inhibitors on cell proliferation. (A) HeLa cells were seeded at 250 cells/mL in the presence or absence of 100 uM of the indicated test compound. After 10-14 days, cell colonies were fixed with formaldehyde and stained with crystal violet. Colonies were counted and normalized to the controls for each experiment. Data represent mean ± SD from 3 experiments. # indicates statistical significance compared to untreated controls p ≤ 0.01. C, Control. (B) Fluorescence quenching of ERK2 in the presence of test compounds. Data show the mean ± SD for percent fluorescence quenching as compared to ERK2 fluorescence in the presence of vehicle (DMSO) from 3 independent experiments.

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