Table 1 Information of the genes studied in relation to tumorigenesis.

DHRS3

Short-chain dehydrogenases/reductase

Melanoma cell lines [17]

Enzyme involved in retinol metabolism. Putative TSG, crucial for the development of neural crest cells, located in NB SRO of deletions [16, 18]. Recently reported as one of three candidate genes that were significantly overexpressed in favorable NB [19].

DUSP23

Dual-specificity protein phosphatase

Role in mitogenic signalling & cell cycle control. Fetal expression - possible role in early development [25, 26].

TGFBI

Extracellular matrix protein

Leukemia, renal cell-, lung-, esophageal cancer [24]

Involved in cell adhesion and tumorigenesis [14, 15]. Reduces proliferation and invasion in vitro and in vivo in NB. The mRNA expression of TGFBI is inversely correlated to MYCN expression in NB [19].

COL1A2

Type I collagen

Medulloblastoma, colorectal- breast- and bladder cancer, melanoma [13, 21, 23, 29]

Tumors that secrete the gene have low tumorigeneic potential [27].

PRKCDBP

Protein kinase binding

Breast-, lung-, ovarian- and gastric cancer, glioblastoma multiforme [20, 31, 35–37]

Also called hSRBC. Putative TSG.

SCNN1A

Ion transport

Breast cancer [22]

Contributes to methylator phenotype in breast cancer [22].

POU2F2

Transcription factor

Regulator of neuronal differentiation [34].

KRT19

Intermediate filament protein

Renal cell carcinoma [30]

Involved in cell migration, invasion and metastasis [28]. Used as biomarker for detection of disseminated tumor cells [33]. Low expression in MNA NB [32].