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Table 1 Information of the genes studied in relation to tumorigenesis.

From: Identification of epigenetically regulated genes that predict patient outcome in neuroblastoma

Symbol Chr Role Methylated in other cancers Comment
DHRS3 1p36 Short-chain dehydrogenases/reductase Melanoma cell lines [17] Enzyme involved in retinol metabolism. Putative TSG, crucial for the development of neural crest cells, located in NB SRO of deletions [16, 18]. Recently reported as one of three candidate genes that were significantly overexpressed in favorable NB [19].
DUSP23 1q23 Dual-specificity protein phosphatase   Role in mitogenic signalling & cell cycle control. Fetal expression - possible role in early development [25, 26].
TGFBI 5q31 Extracellular matrix protein Leukemia, renal cell-, lung-, esophageal cancer [24] Involved in cell adhesion and tumorigenesis [14, 15]. Reduces proliferation and invasion in vitro and in vivo in NB. The mRNA expression of TGFBI is inversely correlated to MYCN expression in NB [19].
COL1A2 7q22 Type I collagen Medulloblastoma, colorectal- breast- and bladder cancer, melanoma [13, 21, 23, 29] Tumors that secrete the gene have low tumorigeneic potential [27].
PRKCDBP 11p15 Protein kinase binding Breast-, lung-, ovarian- and gastric cancer, glioblastoma multiforme [20, 31, 3537] Also called hSRBC. Putative TSG.
SCNN1A 12p13 Ion transport Breast cancer [22] Contributes to methylator phenotype in breast cancer [22].
POU2F2 19q13 Transcription factor   Regulator of neuronal differentiation [34].
KRT19 17q21 Intermediate filament protein Renal cell carcinoma [30] Involved in cell migration, invasion and metastasis [28]. Used as biomarker for detection of disseminated tumor cells [33]. Low expression in MNA NB [32].
  1. TSG, tumor suppressor gene; NB, neuroblastoma; SRO, shortest region of overlap; MNA, MYCN-amplified