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Table 2 Claudin-7 mRNA levels in normal and affected tissues normalised to the β-actin mRNA level.

From: The level of claudin-7 is reduced as an early event in colorectal carcinogenesis

Variable mRNA level in normal tissue Mean ± S.D. Pa mRNA level in adenomas/carcinomas Mean ± S.D. Pa Pb
Healthy individuals 1.19 ± 0.70     
Individuals with mild/moderate dysplasia 1.24 ± 0.67 NS 0.84 ± 0.58 NS <0.001
Individuals with severe dysplasia 1.34 ± 0.75 NS 0.87 ± 0.69 NS <0.01
Cancer patients 0.82 ± 0.73 (distant)
0.83 ± 0.66 (adjacent)
NS
NS
0.44 ± 0.48
"
<0.001 <0.01
<0.001
  1. NS = not significant.
  2. a) p value for the comparison to the expression levels in tissue from healthy individuals using Kruskal Wallis and Dunn's Multiple Comparison test.
  3. b) p value for the comparison of the expression levels in normal and affected tissue from the same individual using Paired Student's t-test.