Gene Name
|
IL-3
|
BCR-ABL
|
TEL-PDGFRB
|
TEL-JAK2
|
---|
Dok2
|
-
|
Up*
|
-
|
-
|
Daf1
|
-
|
Up
|
Down
|
-
|
Ndrg1
|
-
|
Up
|
Down
|
-
|
Stat1
|
-
|
-
|
Up
|
-
|
Gbp1
|
-
|
-
|
Up
|
?
|
Isg20
|
-
|
-
|
Up
|
Up
|
Id1
|
Up*
|
Up
|
Up*
|
-
|
Mrvi1
|
-
|
Up
|
Up
|
-
|
Gp49b
|
Up
|
Up*
|
-
|
Up
|
Cxcl10
|
-
|
Up
|
Up
|
Up
|
Scin
|
-
|
Down
|
Down
|
Down
|
Col5a1
|
Down
|
Down
|
Down*
|
-
|
- All genes were validated by Q-PCR using RNA samples extracted from 2-5 distinct cell populations. Data represent mean fold-change in gene expression at 1 week compared to the expression at 0 h and SEM. All changes in gene expression were associated with p-value < 0.05 as determined by a student t-test unless indicated by asterisk, which denotes p-value < 0.1. Dotted line (-) indicates no significant change
- In addition, Cxcl10 was confirmed to be induced by all three fusions even though it was initially identified as a TEL-PDGFRB-regulated gene (Tables 2 & 5).