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Table 3 Induction of Interferon-Stimulated Genes downstream of TEL-PDGFRB.

From: Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

Gene Description Fold-induction
Chemokine (C-X-C motif) ligand 10 (Cxcl10) 234.5
Guanylate nucleotide binding protein 1 (Gbp1) 103.1
Guanylate nucleotide binding protein 2 (Gbp2) 53.0
Signal transducer and activator of transcription 1 (Stat1) 19.0
Interferon-regulatory factor 7 (Irf7) 14.6
Myxovirus-resistance 1 (Mx1) 10.1
Isg15 ubiquitin-like modifier (Isg15) 8.2
HLA, Class I, G (Hla-g) 7.2
Proteasome subunit, beta type 9 (Psmb9) 6.3
Proteasome subunit, beta type 10 (Psmb10) 5.7
Lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp) 4.6
Caspase 4 (Casp4) 4.4
Interferon-induced protein with tetratricopeptide repeats 2 (Ifit2) 4.3
Nicotinamide phosphoribosyltransferase (Nampt) 4.3
Interferon-regulatory factor 1 (Irf1) 4.2
Tyrosyl tRNA synthetase (Yars) 4.1
Tripartite motif containing 21 3.7
N-myc and Stat interactor (Nmi) 3.3
Pml transcription factor (Pml) 3.1
Tryptophanyl tRNA synthetase (Wars) 2.8
Eif2 alpha kinase 3 (Eif2ak3) 2.6
Proteasome subunit, beta type 8 (Psmb8) 2.4
Proteasome 28 subunit, alpha (Psme1) 2.3
Interferon regulatory factor 9 (Irf9) 2.2
Protein phosphatase 5, catalytic subunit (Ppp5c) 2.2
  1. Genes regulated by TEL-PDGFRB that were previously reported to be ISGs were identified. Data represent the fold-changes in gene expression at steady state obtained from the microarray experiment
  2. All three genes were induced by TEL-PDGFRB as confirmed by Q-PCR (Table 2). Interestingly, the expression of Cxcl10 was similarly elevated downstream of BCR-ABL, whereas the induction of Stat1 and Gbp1 was observed uniquely downstream of TEL-PDGFRB (see summary in Table five).