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Table 3 Induction of Interferon-Stimulated Genes downstream of TEL-PDGFRB.

From: Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

Gene Description

Fold-induction

Chemokine (C-X-C motif) ligand 10 (Cxcl10)

234.5

Guanylate nucleotide binding protein 1 (Gbp1)

103.1

Guanylate nucleotide binding protein 2 (Gbp2)

53.0

Signal transducer and activator of transcription 1 (Stat1)

19.0

Interferon-regulatory factor 7 (Irf7)

14.6

Myxovirus-resistance 1 (Mx1)

10.1

Isg15 ubiquitin-like modifier (Isg15)

8.2

HLA, Class I, G (Hla-g)

7.2

Proteasome subunit, beta type 9 (Psmb9)

6.3

Proteasome subunit, beta type 10 (Psmb10)

5.7

Lectin, galactoside-binding, soluble, 3 binding protein (Lgals3bp)

4.6

Caspase 4 (Casp4)

4.4

Interferon-induced protein with tetratricopeptide repeats 2 (Ifit2)

4.3

Nicotinamide phosphoribosyltransferase (Nampt)

4.3

Interferon-regulatory factor 1 (Irf1)

4.2

Tyrosyl tRNA synthetase (Yars)

4.1

Tripartite motif containing 21

3.7

N-myc and Stat interactor (Nmi)

3.3

Pml transcription factor (Pml)

3.1

Tryptophanyl tRNA synthetase (Wars)

2.8

Eif2 alpha kinase 3 (Eif2ak3)

2.6

Proteasome subunit, beta type 8 (Psmb8)

2.4

Proteasome 28 subunit, alpha (Psme1)

2.3

Interferon regulatory factor 9 (Irf9)

2.2

Protein phosphatase 5, catalytic subunit (Ppp5c)

2.2

  1. Genes regulated by TEL-PDGFRB that were previously reported to be ISGs were identified. Data represent the fold-changes in gene expression at steady state obtained from the microarray experiment
  2. All three genes were induced by TEL-PDGFRB as confirmed by Q-PCR (Table 2). Interestingly, the expression of Cxcl10 was similarly elevated downstream of BCR-ABL, whereas the induction of Stat1 and Gbp1 was observed uniquely downstream of TEL-PDGFRB (see summary in Table five).